ArticleInvestigative ophthalmology & visual science2013
Longitudinal hemodynamic changes within the optic nerve head in experimental glaucoma.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 47 citations in OpenAlex.
- Extravascular Motion Signal Detected by OCT Angiography Indicates Altered Vascular-Tissue Biomechanical Interactions in Glaucoma.Investigative ophthalmology & visual science · 2026Article
- Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma.Investigative ophthalmology & visual science · 2026Article
- Nonaxonal content of the circumpapillary retinal nerve fiber layer in experimental glaucoma.Optometry and vision science : official publication of the American Academy of Optometry · 2026Article
- Relations Between Pulsatility in the Optic Nerve Head or Peripapillary Retinal Vessels and the Rate of Progression in Glaucoma.Investigative ophthalmology & visual science · 2025Article
- Early Peripapillary Choroidal Thinning during Myopia Development: A Potential Biomarker for Progressive Myopia Identified in Tree Shrews.Investigative ophthalmology & visual science · 2025Article
- Changes in vascular resistance with intraocular pressure and damage severity in experimental glaucoma.Experimental eye research · 2025Article
- Vascular resistance indices are higher in the superior than inferior optic nerve head and retina.Experimental eye research · 2024Article
- Assessment of Time Lag Between Blood Flow, Retinal Nerve Fiber Layer Thickness and Visual Field Sensitivity Changes in Glaucoma.Investigative ophthalmology & visual science · 2024Article
- Multifunctional adaptive optics optical coherence tomography allows cellular scale reflectometry, polarimetry, and angiography in the living human eye.Biomedical optics express · 2024Article
- Utility of Light-Adapted Full-Field Electroretinogram ON and OFF Responses for Detecting Glaucomatous Functional Damage.Translational vision science & technology · 2023Article
- Retinal Vessel Pulsatile Characteristics Associated With Vascular Stiffness Can Predict the Rate of Functional Progression in Glaucoma Suspects.Investigative ophthalmology & visual science · 2023Article
- Fractal Dimension of Peripapillary Vasculature in Primary Open-Angle Glaucoma.Korean journal of ophthalmology : KJO · 2022Article
- Methods to measure blood flow and vascular reactivity in the retina.Frontiers in medicine · 2022Review
- Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity.Investigative ophthalmology & visual science · 2021Article
- Vascular Aspects in Glaucoma: From Pathogenesis to Therapeutic Approaches.International journal of molecular sciences · 2021Review
- Quantification of Translaminar Pressure Gradient (TLPG) With Continuous Wireless Telemetry in Nonhuman Primates (NHPs).Translational vision science & technology · 2020Article
- Increased Optic Nerve Head Capillary Blood Flow in Early Primary Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2019Article
- Retinal VEGF levels correlate with ocular circulation measured by a laser speckle-micro system in an oxygen-induced retinopathy rat model.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Article
- The connective tissue phenotype of glaucomatous cupping in the monkey eye - Clinical and research implications.Progress in retinal and eye research · 2017Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo characterize longitudinal changes in basal blood flow (BF) of the optic nerve head (ONH) during progression of structural damage in experimental glaucoma (EG).
methodsUnilateral elevation of IOP was induced in 15 adult rhesus macaques by laser treatment to the trabecular meshwork. Prior to and after laser, retinal nerve fiber layer thickness (RNFLT) and ONH BF were measured biweekly by spectral-domain optical coherence tomography and a laser speckle flowgraphy device (LSFG), respectively.
resultsAverage postlaser IOP was 20.2 ± 5.9 mm Hg in EG eyes and 12.3 ± 2.6 mm Hg in control eyes (P < 0.0001). Longitudinal changes in basal ONH BF were strongly associated with changes in RNFLT as EG progressed from early through moderately advanced stages of damage, with Pearson correlation coefficients ranging from 0.64 to 0.97 (average = 0.81) and an average slope of 1.0. During early stage (RNFLT loss < 10%), basal ONH BF was mildly increased (9% ± 10%, P = 0.004) relative to baseline and compared with fellow controls (P = 0.02). Basal ONH BF declined continuously throughout subsequent stages in EG eyes reaching 25.0% ± 9.6% (P < 0.0001) below baseline at the final stage studied (RNFLT loss > 40%). In fellow control eyes, there was no significant change in basal ONH BF over time (P = 0.27).
conclusionsIn EG based on chronic mild-to-moderate IOP elevation, a two-phase pattern of ONH BF alteration was observed. ONH BF increased during the earliest stage (while RNFLT was within 10% of baseline) followed by a linear decline that was strongly correlated with loss of RNFLT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.