ArticleGenome biology and evolution2013
Microhomology-mediated intron loss during metazoan evolution.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Intron turnover of slc26a1 and slc26a2 and convergence of intron insertion sites.Scientific reports · 2025Article
- RNA transcripts serve as a template for double-strand break repair in human cells.Nature communications · 2025Article
- Intron losses and gains in the nematodes.Biology direct · 2022Article
- Different DNA repair pathways are involved in single-strand break-induced genomic changes in plants.The Plant cell · 2021Article
- The multicomparative 2-n-way genome suite.Genome research · 2020Article
- Evolutionary Dynamics of the SKN-1 → MED → END-1,3 Regulatory Gene Cascade inG3 (Bethesda, Md.) · 2020Article
- Parallel loss of introns in the ABCB1 gene in angiosperms.BMC evolutionary biology · 2017Article
- Regulation of non-homologous end joining via post-translational modifications of components of the ligation step.Current genetics · 2017Review
- Evaluation of the mechanisms of intron loss and gain in the social amoebae Dictyostelium.BMC evolutionary biology · 2015Article
- Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?Trends in biochemical sciences · 2015Review
- Intron evolution in Saccharomycetaceae.Genome biology and evolution · 2014Article
- Article
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2 authors.
Funding
Abstract
How introns are lost from eukaryotic genomes during evolution remains an enigmatic question in biology. By comparative genome analysis of five Caenorhabditis and eight Drosophila species, we found that the likelihood of intron loss is highly influenced by the degree of sequence homology at exon-intron junctions: a significant elevated degree of microhomology was observed for sequences immediately flanking those introns that were eliminated from the genome of one or more subspecies. This determinant was significant even at individual nucleotides. We propose that microhomology-mediated DNA repair underlies this phenomenon, which we termed microhomology-mediated intron loss. This hypothesis is further supported by the observations that in both species 1) smaller introns are preferentially lost over longer ones and 2) genes that are highly transcribed in germ cells, and are thus more prone to DNA double strand breaks, display elevated frequencies of intron loss. Our data also testify against a prominent role for reverse transcriptase-mediated intron loss in metazoans.
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