ArticleJournal of biomedical materials research. Part A2014
A biodegradable thermoset polymer made by esterification of citric acid and glycerol.
Article in Journal of biomedical materials research. Part A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Photo/Biohybrid Catalytic System for Application in Semiartificial Photosynthesis of COChemical reviews · 2026Review
- Preparation, Reaction Kinetics, and Properties of Polyester Foams Using Water Produced by the Reaction as a Foaming Agent.Polymers · 2025Article
- Sonochemical Functionalization of SiOMaterials (Basel, Switzerland) · 2025Article
- Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Synthesis and Characterization of Triticale Starch-Based Hydrogel for pH Responsive Controlled Diffusion.ACS omega · 2024Article
- Flexible Polyurethane Foams Modified with Novel Coconut Monoglycerides-Based Polyester Polyols.ACS omega · 2024Article
- Revealing the Structure Formation on Polyglycerol Citrate Polymers-An Environmentally Friendly Polyester as a Seed-Coating Material.Polymers · 2023Article
- Bio-Based Phosphate-Containing Polyester for Improvement of Fire Reaction in Wooden Particleboard.Polymers · 2023Article
- Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering.Bioactive materials · 2023Review
- Citric Acid: A Multifunctional Pharmaceutical Excipient.Pharmaceutics · 2022Review
- Quantifying the Shape Memory Performance of a Three-Dimensional-Printed Biobased Polyester/Cellulose Composite Material.3D printing and additive manufacturing · 2021Article
- Natural bio-based monomers for biomedical applications: a review.Biomaterials research · 2021Review
- Citrate Crosslinked Poly(Glycerol Sebacate) with Tunable Elastomeric Properties.Macromolecular bioscience · 2021Article
- Poly(Glycerol Succinate) as an Eco-Friendly Component of PLLA and PLCL Fibres towards Medical Applications.Polymers · 2020Article
- Review
- Monosaccharides Dehydration Assisted by Formation of Borate Esters of α-Hydroxyacids in Choline Chloride-Based Low Melting Mixtures.Frontiers in chemistry · 2020Article
- Esterification of citric acid with locust bean gum.Heliyon · 2019Article
- Wet-Dry Cycling Delays the Gelation of Hyperbranched Polyesters: Implications to the Origin of Life.Life (Basel, Switzerland) · 2019Article
- Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hy-droxy-propane-1,2,3-tri-carboxyl-ate).Acta crystallographica. Section E, Crystallographic communications · 2018Article
- Design Strategies and Applications of Biomaterials and Devices for Hernia Repair.Bioactive materials · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A new biomaterial, a degradable thermoset polymer, was made from simple, economical, biocompatable monomers without the need for a catalyst. Glycerol and citric acid, nontoxic and renewable reagents, were crosslinked by a melt polymerization reaction at temperatures from 90 to 150°C. Consistent with a condensation reaction, water was determined to be the primary byproduct. The amount of crosslinking was controlled by the reaction conditions, including temperature, reaction time, and ratio between glycerol and citric acid. Also, the amount of crosslinking was inversely proportional to the rate of degradation. As a proof-of-principle for drug delivery applications, gentamicin, an antibiotic, was incorporated into the polymer with preliminary evaluations of antimicrobial activity. The polymers incorporating gentamicin had significantly better bacteria clearing of Staphylococcus aureus compared to non-gentamicin gels for up to 9 days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.