ReviewComprehensive Physiology2011
Reactive oxygen species: impact on skeletal muscle.
Review in Comprehensive Physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05592509 (Evaluation of the Antioxidant Effect of a Mixture of Ozonated Vegetable Oil and Vitamin Complex), which is not on this map. Cited by 271 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Antioxidant Effect of a Mixture of Ozonated Vegetable Oil and Vitamin Complex (Vitamin K2 and Vitamin B9) in Moderately Active Subjects With "Physical Activity Level" (LAF: 1.70-1.99): Pilot Study
Who cites it
271 citing papers in PubMed, 5 syntheses or guidelines pooled it, 456 citations in OpenAlex.
- Pooled it
- Pooled it
- Pooled it
- Flavonoid Containing Polyphenol Consumption and Recovery from Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Ischemia-Reperfusion Intervention: From Enhancements in Exercise Performance to Accelerated Performance Recovery-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Trial
- Trial
- The Impact of 5-Aminolevulinic Acid Supplementation on Redox Balance and Aerobic Capacity.International journal of molecular sciences · 2024Trial
- Trial
- Effects of Blood Flow Restriction Training with Protein Supplementation on Muscle Mass And Strength in Older Men.Journal of sports science & medicine · 2019Trial
- International Society of Sports Nutrition position stand: effects of dietary antioxidants on exercise and sports performance.Journal of the International Society of Sports Nutrition · 2026Review
- Multilevel regulation of skeletal muscle ferroptosis in aging: sex- and exercise-dependent effects on histological, molecular, and genetic markers.GeroScience · 2026Article
- Mito-Nuclear Interactions in Livestock: Implications for Adaptation, Productivity, and Precision Breeding.International journal of molecular sciences · 2026Review
- Exercise training does not mitigate high-phosphate diet-induced mitochondrial dysfunction in skeletal muscle in male mice.Physiological reports · 2026Article
- The hallmarks of skeletal muscle health.Nature metabolism · 2026Review
- Click-crosslinked nanogels integrated into 3D stem cell spheroids enhance regenerative function for swallowing muscle repair.Biomaterials · 2026Article
- Pushing athletic performance boundaries with anodal transcranial direct current stimulation: an exploratory, pilot, randomized controlled study on strength and inflammation in elite weightlifters.BMC sports science, medicine & rehabilitation · 2026Article
- Tuning the Fire: Context-Dependent Mitochondrial ROS Signaling, Mitohormesis, and Redox-Modulating Interventions.Biomolecules · 2026Review
- Vitamin D deficiency modifies the association between ambient PMNutrition research and practice · 2026Article
- Oxidative Stress and Diminished Mitochondrial Proteostatic Reserve Are Linked to Enhanced mtUPR Initiation in Aged Mouse Muscle.Aging cell · 2026Article
211 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
It is well established that contracting muscles produce both reactive oxygen and nitrogen species. Although the sources of oxidant production during exercise continue to be debated, growing evidence suggests that mitochondria are not the dominant source. Regardless of the sources of oxidants in contracting muscles, intense and prolonged exercise can result in oxidative damage to both proteins and lipids in the contracting myocytes. Further, oxidants regulate numerous cell signaling pathways and modulate the expression of many genes. This oxidant-mediated change in gene expression involves changes at transcriptional, mRNA stability, and signal transduction levels. Furthermore, numerous products associated with oxidant-modulated genes have been identified and include antioxidant enzymes, stress proteins, and mitochondrial electron transport proteins. Interestingly, low and physiological levels of reactive oxygen species are required for normal force production in skeletal muscle, but high levels of reactive oxygen species result in contractile dysfunction and fatigue. Ongoing research continues to explore the redox-sensitive targets in muscle that are responsible for both redox regulation of muscle adaptation and oxidant-mediated muscle fatigue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.