ArticlePathology oncology research : POR2013
Overexpression of metastasis-associated in colon cancer-1 associated with poor prognosis in patients with esophageal cancer.
Article in Pathology oncology research : POR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- MACC1 overexpression and survival in solid tumors: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- Prognostic Value of MACC1 in Digestive System Neoplasms: A Systematic Review and Meta-Analysis.BioMed research international · 2015Pooled it
- Mitochondria-related genes as prognostic signature of endometrial cancer and the effect of MACC1 on tumor cells.PloS one · 2025Article
- Article
- MACC1 Promotes the Progression and Is a Novel Biomarker for Predicting Immunotherapy Response in Colorectal Cancer.Journal of oncology · 2022Article
- The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC.Analytical cellular pathology (Amsterdam) · 2022Article
- MACC1 and HGF are associated with survival in patients with gastric cancer.Oncology letters · 2018Article
- Prognostic Characteristics of MACC1 Expression in Epithelial Ovarian Cancer.BioMed research international · 2018Article
- miR-338-3p suppresses colorectal cancer proliferation and progression by inhibiting MACC1.International journal of clinical and experimental pathology · 2018Article
- Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer.Oncology letters · 2017Article
- Article
- Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.PLoS biology · 2017Article
- miR-433 reduces cell viability and promotes cell apoptosis by regulating MACC1 in colorectal cancer.Oncology letters · 2017Article
- Metastasis-associated in colon cancer-1 in gastric cancer: Beyond metastasis.World journal of gastroenterology · 2016Review
- Genomic Profiling of Thyroid Cancer Reveals a Role for Thyroglobulin in Metastasis.American journal of human genetics · 2016Article
- MACC1 upregulation promotes gastric cancer tumor cell metastasis and predicts a poor prognosis.Journal of Zhejiang University. Science. B · 2016Article
- Observational
- The potential therapeutic applications and prognostic significance of metastasis-associated in colon cancer-1 (MACC1) in cancers.Contemporary oncology (Poznan, Poland) · 2016Review
- Circulating MACC1 as a novel diagnostic and prognostic biomarker for nonsmall cell lung cancer.Journal of cancer research and clinical oncology · 2015Article
- Positive MACC1 expression correlates with invasive behaviors and postoperative liver metastasis in colon cancer.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have shown that expression of metastasis-associated in colon cancer-1(MACC1) is observed in different types of cancer and plays an important role in tumor metastasis. However, the expression of MACC1 and its possible role in esophageal cancer remains unknown. In this study, we determined the expression of MACC1 in esophageal cancer by utilizing immunohistochemistry and analyzed the relationship between the expression and esophageal cancer prognosis. Immunohistochemistry results showed that 47 of 85 cancer lesions (55.2 %) were stained positive, and high expression of MACC1 was correlated with the node metastasis and TNM stage (P < 0.05). The Kaplan-Meier survival curve showed that patients with high MACC1 expression had significantly reduced overall 5-year survival rates (P = 0.004). Cox regression analysis revealed that high expression of MACC1 was associated with increased risk of death (hazard ratio [HR] =2.25) in patients with esophageal cancer. These findings suggested that high expression of MACC1 was correlated with progression and metastasis of esophageal cancer and might serve as a novel prognostic marker for patients with esophageal cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.