ArticleAge (Dordrecht, Netherlands)2014
Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging.
Article in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Epigenetic Clocks Can Predict Age in the Largemouth Bass-Complex Despite Spatial and Sexual Variation.Evolutionary applications · 2026Article
- Whole-genome DNA methylation profile of female Gobiocypris rarus brains at three age stages.Scientific data · 2026Article
- Gene-specific DNA methylation responses to PbEnvironmental epigenetics · 2026Article
- Epigenome-wide association study of nuclear DNA methylation in relation to mitochondrial heteroplasmy.Nature communications · 2025Article
- Fins as a reliable surrogate tissue for age-related changes of telomeres and DNA methylation in gonads of a short-lived fish.Biogerontology · 2025Article
- Independent Avian Epigenetic Clocks for Ageing and Development.Molecular ecology resources · 2025Article
- Implications of Lead (Pb)-Induced Transcriptomic and Phenotypic Alterations in the Aged Zebrafish (Toxics · 2024Article
- Exploring Multifunctional Markers of Biological Age in Farmed Gilthead Sea Bream (International journal of molecular sciences · 2024Article
- Advances in environmental DNA monitoring: standardization, automation, and emerging technologies in aquatic ecosystems.Science China. Life sciences · 2024Review
- Age group DNA methylation differences in lemon sharks (Ecology and evolution · 2022Article
- Dynamic changes of genomic methylation profiles at different growth stages in Chinese Tan sheep.Journal of animal science and biotechnology · 2021Article
- Modeling Neuroregeneration and Neurorepair in an Aging Context: The Power of a Teleost Model.Frontiers in cell and developmental biology · 2021Review
- Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio).GeroScience · 2020Article
- Population-level inferences from environmental DNA-Current status and future perspectives.Evolutionary applications · 2020Review
- Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer's disease patients.PloS one · 2020Article
- DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons.Frontiers in cell and developmental biology · 2020Article
- Genetic and epigenetic regulation of human aging and longevity.Biochimica et biophysica acta. Molecular basis of disease · 2019Review
- Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2018Article
- Regulation of neuronal survival by DNA methyltransferases.Neural regeneration research · 2017Review
- Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related changes in DNA methylation have been demonstrated in mammals, but it remains unclear as to the generality of this phenomenon in vertebrates, which is a criterion for the fundamental cause of senescence. Here we showed that the zebrafish genome gradually and clearly lost methylcytosine in somatic cells, but not in male germ cells during aging, and that age-dependent hypomethylation preferentially occurred at a particular domain called the CpG island shore, which is associated with vertebrates' genes and has been shown to be hypomethylated in humans with age. We also found that two CpG island shores hypomethylated in zebrafish oocytes were de novo methylated in fertilized eggs, which suggests that the zebrafish epigenome is reset upon fertilization, enabling new generations to restart with a heavily methylated genome. Furthermore, we observed an increase in cleavage of the zebrafish genome to an oligonucleosome length in somatic cells from the age of 12 months, which is suggestive of an elevated rate of apoptosis in the senescent stage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.