ArticleJournal of gastroenterology2014
Helicobacter pylori infection is positively associated with gallstones: a large-scale cross-sectional study in Japan.
Article in Journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Pooled it
- The Relationship betweenCanadian journal of gastroenterology & hepatology · 2021Pooled it
- Porcelain gallbladder revisited.Journal of ultrasound · 2026Review
- Research progress on the role of microbiota in the pathogenesis of gallstone disease.Frontiers in microbiology · 2025Review
- The link betweenAnnals of hepato-biliary-pancreatic surgery · 2023Review
- Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study.PloS one · 2022Article
- Prevalence and risk factors of gallbladder polyps in primary health care centers among patients examined by abdominal ultrasonography in Qatar: a case-control study.Qatar medical journal · 2021Article
- Article
- Gallstone Disease and Microbiome.Microorganisms · 2020Review
- Nonalcoholic Fatty Liver Disease Is Associated withGastroenterology research and practice · 2020Article
- Review
- Prevalence and Risk Factors of Gallbladder Polypoid Lesions in a Healthy Population.Yonsei medical journal · 2016Article
- Atrophic gastritis and enlarged gastric folds diagnosed by double-contrast upper gastrointestinal barium X-ray radiography are useful to predict future gastric cancer development based on the 3-year prospective observation.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Observational
- Comparative analysis of upper gastrointestinal endoscopy, double-contrast upper gastrointestinal barium X-ray radiography, and the titer of serum anti-Helicobacter pylori IgG focusing on the diagnosis of atrophic gastritis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Article
- Gallstones: new insights into an old story.F1000Research · 2016Review
- Cholecystectomy and duodenogastric reflux: interacting effects over the gastric mucosa.SpringerPlus · 2016Article
- Helicobacter pylori infection is associated with gallstones: Epidemiological survey in China.World journal of gastroenterology · 2015Article
- Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan.BMC gastroenterology · 2015Article
- Article
- Prevalence of and risk factors for gallstones in Uighur and Han Chinese.World journal of gastroenterology · 2014Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur aim is to elucidate causative factors for gallstones, especially focusing on Helicobacter pylori (HP) infection.
methodsWe analyzed 15,551 Japanese adults who had no history of gastrectomy, cholecystectomy, HP eradication, and didn't use proton pump inhibitors, anti-diabetic drugs, or anti-cholesterol drugs. 1,057 subjects who previously had HP eradication were analyzed separately.
resultsGallstones were detected in 409 of 8,625 men (4.74%) and 285 of 6,926 women (4.11%) by ultrasonography. Among the 25 factors univariately analyzed, age, HP infection, alcohol intake, weight, body mass index (BMI), and 14 blood test values (AST, ALT, ALP, γ-GTP, T-Chol, HDL-Chol, LDL-Chol, TG, TP, Hb, HbA1c, pepsinogen I, pepsinogen II, and pepsinogen I/II ratio) displayed significant association with gallstones (p < 0.05), whereas gender, smoking, height, and three blood test values (Alb, T-Bil, MCV) did not. Multivariate analysis showed that age, gender, alcohol intake, BMI, γ-GTP, LDL-Chol, TP, and HP infection had significant association (p < 0.05). Successive multiple logistic regression analysis calculating odds ratio (OR) and standardized coefficients (β) showed that age (OR/β = 1.57/0.450), BMI (OR/β = 1.30/0.264), HP infection (OR/β = 1.51/0.206), lower alcohol intake (OR/β = 1.33/0.144), γ-GTP (OR/β = 1.15/0.139), and pepsinogen I/II ratio (OR/β = 1.08/0.038) have significant positive association with gallstones, whereas gender does not. The gallstone prevalence among HP-negative, HP-eradicated, and HP-positive subjects was 3.81, 4.73 and 6.08%, respectively. The matched analysis controlling age, BMI, γ-GTP, alcohol intake, pepsinogen I/II ratio and gender also demonstrated that gallstone prevalence among HP-eradicated subjects was significantly lower compared with HP-positive subjects (p < 0.05).
conclusionsHP infection is positively associated with gallstones. HP eradication may lead to prevention of gallstones.
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