ArticleMarine drugs2013
The extract of Rhodobacter sphaeroides inhibits melanogenesis through the MEK/ERK signaling pathway.
Article in Marine drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Regulatory effects ofInternational journal of medical sciences · 2021Trial
- Applications of Probiotic Constituents in Cosmetics.Molecules (Basel, Switzerland) · 2023Review
- Review
- Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms.Frontiers in physiology · 2023Review
- Deoxyvasicinone with Anti-Melanogenic Activity from Marine-DerivedMarine drugs · 2022Article
- Dermal Drug Delivery of Phytochemicals with Phenolic Structure via Lipid-Based Nanotechnologies.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Anti-Pigmentary Natural Compounds and Their Mode of Action.International journal of molecular sciences · 2021Review
- Rice Bran Ash Mineral Extract Increases Pigmentation through the p-ERK Pathway in Zebrafish (International journal of molecular sciences · 2019Article
- Pulsed Electromagnetic Fields Increase Pigmentation through the p-ERK/p-p38 Pathway in Zebrafish (International journal of molecular sciences · 2018Article
- A Zebrafish Embryo as an Animal Model for the Treatment of Hyperpigmentation in Cosmetic Dermatology Medicine.Medicina (Kaunas, Lithuania) · 2018Review
- Rhodobacter sphaeroides Extract Lycogen™ Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats.International journal of molecular sciences · 2018Article
- Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cells.International journal of medical sciences · 2018Article
- The Extracts ofInternational journal of medical sciences · 2017Article
- The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders.International journal of molecular sciences · 2016Review
- Hinokitiol Inhibits Melanogenesis via AKT/mTOR Signaling in B16F10 Mouse Melanoma Cells.International journal of molecular sciences · 2016Article
- Skin microbiota of first cousins affected by psoriasis and atopic dermatitis.Clinical and molecular allergy : CMA · 2016Article
- Biofunctional Activities of Equisetum ramosissimum Extract: Protective Effects against Oxidation, Melanoma, and Melanogenesis.Oxidative medicine and cellular longevity · 2016Article
- Dual effects of acetylsalicylic acid on ERK signaling and Mitf transcription lead to inhibition of melanogenesis.Molecular and cellular biochemistry · 2016Article
- Genetic associations and shared environmental effects on the skin microbiome of Korean twins.BMC genomics · 2015Article
- Characterization of Melanogenesis Inhibitory Constituents of Morus alba Leaves and Optimization of Extraction Conditions Using Response Surface Methodology.Molecules (Basel, Switzerland) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reducing hyperpigmentation has been a big issue for years. Even though pigmentation is a normal mechanism protecting skin from UV-causing DNA damage and oxidative stress, it is still an aesthetic problem for many people. Bacteria can produce some compounds in response to their environment. These compounds are widely used in cosmetic and pharmaceutical applications. Some probiotics have immunomodulatory activities and modulate the symptoms of several diseases. Previously, we found that the extracts of Rhodobacter sphaeroides (Lycogen™) inhibited nitric oxide production and inducible nitric-oxide synthase expression in activated macrophages. In this study, we sought to investigate an anti-melanogenic signaling pathway in α-melanocyte stimulating hormone (α-MSH)-treated B16F10 melanoma cells and zebrafish. Treatment with Lycogen™ inhibited the cellular melanin contents and expression of melanogenesis-related protein, including microphthalmia-associated transcription factor (MITF) and tyrosinase in B16F10 cells. Moreover, Lycogen™ reduced phosphorylation of MEK/ERK without affecting phosphorylation of p38. Meanwhile, Lycogen™ decreased zebrafish melanin expression in a dose-dependent manner. These findings establish Lycogen™ as a new target in melanogenesis and suggest a mechanism of action through the ERK signaling pathway. Our results suggested that Lycogen™ may have potential cosmetic usage in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.