ArticleInternational journal of molecular sciences2013
Genome-wide investigation of multifocal and unifocal prostate cancer-are they genetically different?
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- ISUP grade upgrade prediction after radical prostatectomy: Role of Luteinizing Hormone to Testosterone ratio.BJUI compass · 2025Article
- Immunohistochemical markers as predictors of prognosis in multifocal prostate cancer.Virchows Archiv : an international journal of pathology · 2024Article
- Systemic Alterations of Wnt Inhibitors in Patients with Prostate Cancer and Bone Metastases.Disease markers · 2018Article
- Vascular targeted photochemotherapy using padoporfin and padeliporfin as a method of the focal treatment of localised prostate cancer - clinician's insight.World journal of methodology · 2016Review
- Exploring prostate cancer genome reveals simultaneous losses of PTEN, FAS and PAPSS2 in patients with PSA recurrence after radical prostatectomy.International journal of molecular sciences · 2015Article
- Clinically relevant genetic characterization of prostate tumors: how close are we to the goal?Korean journal of urology · 2015Review
- Effect of material property heterogeneity on biomechanical modeling of prostate under deformation.Physics in medicine and biology · 2015Article
- Heterogeneity of DNA methylation in multifocal prostate cancer.Virchows Archiv : an international journal of pathology · 2015Article
- High serum levels of Dickkopf-1 are associated with a poor prognosis in prostate cancer patients.BMC cancer · 2014Article
- Clinical and pathologic factors predicting reclassification in active surveillance cohorts.International braz j urol : official journal of the Brazilian Society of UrologyReview
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Authors and funding
11 authors.
Funding
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Abstract
Prostate cancer is widely observed to be biologically heterogeneous. Its heterogeneity is manifested histologically as multifocal prostate cancer, which is observed more frequently than unifocal prostate cancer. The clinical and prognostic significance of either focal cancer type is not fully established. To investigate prostate cancer heterogeneity, the genetic profiles of multifocal and unifocal prostate cancers were compared. Here, we report observations deduced from tumor-tumor comparison of copy number alteration data of both focal categories. Forty-one fresh frozen prostate cancer foci from 14 multifocal prostate cancers and eight unifocal prostate cancers were subjected to copy number variation analysis with the Affymetrix SNP 6.0 microarray tool. With the investigated cases, tumors obtained from a single prostate exhibited different genetic profiles of variable degrees. Further comparison identified no distinct genetic pattern or signatures specific to multifocal or unifocal prostate cancer. Our findings suggest that samples obtained from multiple sites of a single unifocal prostate cancer show as much genetic heterogeneity and variability as separate tumors obtained from a single multifocal prostate cancer.
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