ArticleHuman genetics2013
Genetic epidemiology of cardiometabolic risk factors and their clustering patterns in Mexican American children and adolescents: the SAFARI Study.
Article in Human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Heritability of blood pressure traits in diverse populations: a systematic review and meta-analysis.Journal of human hypertension · 2019Pooled it
- Clinical and Metabolic Characteristics among Mexican Children with Different Types of Diabetes Mellitus.PloS one · 2016Trial
- Association of Ultra-Processed Food Intake with Insulin Secretion and Sensitivity in Mexican American Children: Results from the SAFARI Study.Nutrients · 2026Article
- Familial Associations of Metabolic Syndrome and Its Interrelated Traits in Southwestern Indigenous Americans.The Journal of clinical endocrinology and metabolism · 2025Article
- Early-Life Exposure to Organic Chemical Pollutants as Assessed in Primary Teeth and Cardiometabolic Risk in Mexican American Children: A Pilot Study.International journal of environmental research and public health · 2025Article
- Multilevel prenatal socioeconomic predictors of Mexican American children's cardiometabolic health in preschool and school age.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- Association of BMI trajectories with cardiometabolic risk among low-income Mexican American children.Pediatric research · 2023Article
- Further evidence supporting a potential role for ADH1B in obesity.Scientific reports · 2021Article
- Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children.Scientific reports · 2021Article
- Differences in the prevalence of modifiable risk and protective factors for prostate cancer by race and ethnicity in the National Health and Nutrition Examination Survey.Cancer causes & control : CCC · 2020Article
- Heritability and genome-wide association analyses of fasting plasma glucose in Chinese adult twins.BMC genomics · 2020Article
- Article
- Neighborhoods to Nucleotides - Advances and gaps for an obesity disparities systems epidemiology model.Current epidemiology reports · 2019Article
- Genetic and environmental (physical fitness and sedentary activity) interaction effects on cardiometabolic risk factors in Mexican American children and adolescents.Genetic epidemiology · 2018Article
- Association of interleukin-6 polymorphisms with obesity or metabolic traits in young Mexican-Americans.Obesity science & practice · 2018Article
- Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children.The American journal of clinical nutrition · 2017Article
- Apolipoprotein E4, Gender, Body Mass Index, Inflammation, Insulin Resistance, and Air Pollution Interactions: Recipe for Alzheimer's Disease Development in Mexico City Young Females.Journal of Alzheimer's disease : JAD · 2017Review
- Parental and offspring contribution of genetic markers of adult blood pressure in early life: The FAMILY study.PloS one · 2017Article
- Health Issues in Hispanic/Latino Youth.Journal of Latina/o psychology · 2016Article
- Metabolites as novel biomarkers for childhood obesity-related traits in Mexican-American children.Pediatric obesity · 2015Article
Corrections and comments
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Authors and funding
23 authors at 3 institutions in 1 country.
Funding
Abstract
Pediatric metabolic syndrome (MS) and its cardiometabolic components (MSCs) have become increasingly prevalent, yet little is known about the genetics underlying MS risk in children. We examined the prevalence and genetics of MS-related traits among 670 non-diabetic Mexican American (MA) children and adolescents, aged 6-17 years (49 % female), who were participants in the San Antonio Family Assessment of Metabolic Risk Indicators in Youth study. These children are offspring or biological relatives of adult participants from three well-established Mexican American family studies in San Antonio, TX, at increased risk of type 2 diabetes. MS was defined as ≥3 abnormalities among 6 MSC measures: waist circumference, systolic and/or diastolic blood pressure, fasting insulin, triglycerides, HDL-cholesterol, and fasting and/or 2-h OGTT glucose. Genetic analyses of MS, number of MSCs (MSC-N), MS factors, and bivariate MS traits were performed. Overweight/obesity (53 %), pre-diabetes (13 %), acanthosis nigricans (33 %), and MS (19 %) were strikingly prevalent, as were MS components, including abdominal adiposity (32 %) and low HDL-cholesterol (32 %). Factor analysis of MS traits yielded three constructs: adipo-insulin-lipid, blood pressure, and glucose factors, and their factor scores were highly heritable. MS itself exhibited 68 % heritability. MSC-N showed strong positive genetic correlations with obesity, insulin resistance, inflammation, and acanthosis nigricans, and negative genetic correlation with physical fitness. MS trait pairs exhibited strong genetic and/or environmental correlations. These findings highlight the complex genetic architecture of MS/MSCs in MA children, and underscore the need for early screening and intervention to prevent chronic sequelae in this vulnerable pediatric population.
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