Trial reportAmerican journal of hypertension2013
Blood pressure after recent stroke: baseline findings from the secondary prevention of small subcortical strokes trial.
Trial report in American journal of hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04226157 (Home Blood Pressure Self-Management in Hypertensive Stroke Survivors), which is not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Home Blood Pressure Self-Management in Hypertensive Stroke Survivors: a Pilot Study
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Integrating clinical pharmacists in care management for secondary stroke prevention clinical trials: a scoping review.Frontiers in neurology · 2025Pooled it
- Pooled it
- 7th Brazilian Guideline of Arterial Hypertension: Chapter 8 - Hypertension and Associated Clinical ConditionsArquivos brasileiros de cardiologia · 2016Guideline
- Telehealth After Stroke Care Pilot Randomized Trial of Home Blood Pressure Telemonitoring in an Underserved Setting.Stroke · 2022Trial
- Achieved blood pressures in the secondary prevention of small subcortical strokes (SPS3) study: challenges and lessons learned.American journal of hypertension · 2014Trial
- Postoperative Rebleeding: The Sword of Damocles in Minimally Invasive Surgery for Intracerebral Hemorrhage.Research (Washington, D.C.) · 2026Review
- Article
- Review
- Feasibility of an Application-Based Outpatient Rehabilitation Program for Stroke Survivors: Acceptability and Preliminary Results for Patient-Reported Outcomes.Bioengineering (Basel, Switzerland) · 2024Article
- Investigations of hypoxia-induced deoxyhemoglobin as a contrast agent for cerebral perfusion imaging.Human brain mapping · 2023Article
- Review
- TASC (Telehealth After Stroke Care): a study protocol for a randomized controlled feasibility trial of telehealth-enabled multidisciplinary stroke care in an underserved urban setting.Pilot and feasibility studies · 2022Article
- Rehabilitation of Upper Limb Motor Impairment in Stroke: A Narrative Review on the Prevalence, Risk Factors, and Economic Statistics of Stroke and State of the Art Therapies.Healthcare (Basel, Switzerland) · 2022Review
- Brazilian Guidelines of Hypertension - 2020.Arquivos brasileiros de cardiologia · 2021Article
- Review
- Uncontrolled Blood Pressure in Hypertensive Patients with High Medication Adherence: A Korean Nationwide Population-Based Study.Korean journal of family medicine · 2020Article
- Effect of Postural Hypotension on Recurrent Stroke: Secondary Prevention of Small Subcortical Strokes (SPS3) Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Article
- Article
- Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association.Circulation · 2017Review
- Change in Systolic Blood Pressure During Stroke, Functional Status, and Long-Term Mortality in an Elderly Population.American journal of hypertension · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 14 institutions in 8 countries.
Funding
Abstract
backgroundHypertension is the most powerful risk factor for stroke. The aim of this study was to characterize baseline blood pressure in participants in the Secondary Prevention of Small Subcortical Strokes trial.
methodsFor this cross-sectional analysis, participants were categorized by baseline systolic blood pressure (SBP) < 120, 120-139, 140-159, 160-179, and ≥ 180 mm Hg and compared on demographic and clinical characteristics. Predictors of SBP < 140 mm Hg were examined.
resultsMean SBP was 143±19 mm Hg while receiving an average of 1.7 antihypertensive medications; SBP ≥ 140 mm Hg for 53% and ≥ 160 mm Hg for 18% of the 3,020 participants. Higher SBP was associated with a history of hypertension and hypertension for longer duration (both P < 0.0001). Higher SBPs were associated with more extensive white matter disease on magnetic resonance imaging (P < 0.0001). There were significant differences in entry-level SBP when participants were categorized by race and region (both P < 0.0001). Black participants were more likely to have SBP ≥ 140 mm Hg. Multivariable logistic regression showed an independent effect for region with those from Canada more likely (odds ratio = 1.7; 95% confidence interval, 1.29, 2.32) to have SBP < 140 mm Hg compared with participants from United States.
conclusionsIn this cohort with symptomatic lacunar stroke, more than half had uncontrolled hypertension at approximately 2.5 months after stroke. Regional, racial, and clinical differences should be considered to improve control and prevent recurrent stroke.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.