ArticleDiabetes care2013
Insulin resistance, incident cardiovascular diseases, and decreased kidney function among nondiabetic American Indians: the Strong Heart Study.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Reported sources of health inequities in Indigenous Peoples with chronic kidney disease: a systematic review of quantitative studies.BMC public health · 2021Pooled it
- The role of cardiovascular disease in the association between estimated glucose disposal rate and chronic kidney disease.Scientific reports · 2025Article
- Factors influencing new-onset hypertension in elderly patients with obstructive sleep apnea: A multicenter cohort study.Clinical and translational science · 2023Article
- Insulin resistance, kidney outcomes and effects of the endothelin receptor antagonist atrasentan in patients with type 2 diabetes and chronic kidney disease.Cardiovascular diabetology · 2023Article
- Association of triglyceride-glucose index with myocardial injury post-stroke in older patients with first-ever ischemic stroke.BMC geriatrics · 2023Article
- Ameliorative Effects of Bredemolic Acid on Markers Associated with Renal Dysfunction in a Diet-Induced Prediabetic Rat Model.Oxidative medicine and cellular longevity · 2020Article
- Type 2 diabetes and later cognitive function in older American Indians: The Strong Heart Study.International journal of geriatric psychiatry · 2019Article
- The emerging role of sorting nexins in cardiovascular diseases.Clinical science (London, England : 1979) · 2019Review
- Influencing factors of glycemic variability in hospitalized type 2 diabetes patients with insulin therapy: A Strobe-compliant article.Medicine · 2017Article
- Effect of diabetes and metabolic syndrome on myocardial mechano-energetic efficiency in hypertensive patients. The Campania Salute Network.Journal of human hypertension · 2017Article
- Association of diabetes and cancer mortality in American Indians: the Strong Heart Study.Cancer causes & control : CCC · 2015Article
- Blood inorganic mercury is directly associated with glucose levels in the human population and may be linked to processed food intake.Integrative molecular medicine · 2015Article
- Cardiovascular risk stratification and management in pre-diabetes.Current diabetes reports · 2014 · on this mapReview
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
objectivePrevalence of insulin resistance is high in the American Indian population, likely as a result of the high prevalence of obesity. This condition may be influential for clinical outcomes such as cardiovascular disease (CVD) and decreased kidney function. RESEARCH DESIGN AND
methodsNormal glucose tolerant (NGT) participants free of hypertension and CVD at the baseline examination (1989-1992) (N=964) of the Strong Heart Study were selected to explore the cross-sectional association between insulin resistance quantified by homeostasis model assessment (HOMA-IR) and demographic, behavioral, and cardiometabolic variables. The longitudinal association between baseline HOMA-IR and the development of CVD was also explored. The longitudinal association between baseline HOMA-IR and the development of high urinary albumin-to-creatinine ratio was explored among nondiabetic participants (N=1,401).
resultsCross-sectionally, HOMA-IR was associated with sex, residence location, smoking, and high-risk cardiometabolic profile. Prospectively, insulin resistance is associated with the development of CVD and decreased kidney function in this population.
conclusionsInsulin resistance may have an important role in the pathogenesis of CVD and chronic kidney disease. Since obesity contributes to the development of insulin resistance, intervention focusing on modifiable factors such as physical activity and weight control may reduce the development of these diseases.
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