ArticleJournal of psychiatry & neuroscience : JPN2013
Altered affective, executive and sensorimotor resting state networks in patients with pediatric mania.
Article in Journal of psychiatry & neuroscience : JPN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Network localization of genetic risk for schizophrenia and bipolar disorder.Psychological medicine · 2025Article
- Aberrant Resting-State Functional Connectivity in the Default Mode Network in Pediatric Bipolar Disorder Patients with and without Psychotic Symptoms.Neuroscience bulletin · 2019Article
- Abnormal Degree Centrality Associated With Cognitive Dysfunctions in Early Bipolar Disorder.Frontiers in psychiatry · 2019Article
- Aberrant intrinsic functional connectivity within and between corticostriatal and temporal-parietal networks in adults and youth with bipolar disorder.Psychological medicine · 2016Article
- Contrasting variability patterns in the default mode and sensorimotor networks balance in bipolar depression and mania.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls.PloS one · 2016Article
- Intrinsic Amygdala Functional Connectivity in Youth With Bipolar I Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2015Article
- Aberrant amygdala intrinsic functional connectivity distinguishes youths with bipolar disorder from those with severe mood dysregulation.Psychiatry research · 2015Article
- Decreased amygdala-insula resting state connectivity in behaviorally and emotionally dysregulated youth.Psychiatry research · 2015Article
- Early signs of anomalous neural functional connectivity in healthy offspring of parents with bipolar disorder.Bipolar disorders · 2014Article
- Developmental Resting State Functional Connectivity for Clinicians.Current behavioral neuroscience reports · 2014Article
- Alterations of regional homogeneity in pediatric bipolar depression: a resting-state fMRI study.BMC psychiatry · 2014Article
- A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research.The American journal of psychiatry · 2014Review
- Altered baseline brain activity in children with bipolar disorder during mania state: a resting-state study.Neuropsychiatric disease and treatment · 2014Article
- Meta-analyses of developing brain function in high-risk and emerged bipolar disorder.Frontiers in psychiatry · 2014Article
- Time course of recovery showing initial prefrontal cortex changes at 16 weeks, extending to subcortical changes by 3 years in pediatric bipolar disorder.Journal of affective disorders · 2013Article
Corrections and comments
- Retraction · 2015-11-01Falsification/Fabrication of Results · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author ·
- Retracted
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe aim of the present study was to map the pathophysiology of resting state functional connectivity accompanying structural and functional abnormalities in children with bipolar disorder.
methodsChildren with bipolar disorder and demographically matched healthy controls underwent resting-state functional magnetic resonance imaging. A model-free independent component analysis was performed to identify intrinsically interconnected networks.
resultsWe included 34 children with bipolar disorder and 40 controls in our analysis. Three distinct resting state networks corresponding to affective, executive and sensorimotor functions emerged as being significantly different between the pediatric bipolar disorder (PBD) and control groups. All 3 networks showed hyperconnectivity in the PBD relative to the control group. Specifically, the connectivity of the dorsal anterior cingulate cortex (ACC) differentiated the PBD from the control group in both the affective and the executive networks. Exploratory analysis suggests that greater connectivity of the right amygdala within the affective network is associated with better executive function in children with bipolar disorder, but not in controls. LIMITATIONS: Unique clinical characteristics of the study sample allowed us to evaluate the pathophysiology of resting state connectivity at an early state of PBD, which led to the lack of generalizability in terms of comorbid disorders existing in a typical PBD population.
conclusionAbnormally engaged resting state affective, executive and sensorimotor networks observed in children with bipolar disorder may reflect a biological context in which abnormal task-based brain activity can occur. Dual engagement of the dorsal ACC in affective and executive networks supports the neuroanatomical interface of these networks, and the amygdala's engagement in moderating executive function illustrates the intricate interplay of these neural operations at rest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.