ArticlePhysical biology2013
Follow-the-leader cell migration requires biased cell-cell contact and local microenvironmental signals.
Article in Physical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- PIEZO1 regulates leader cell formation and cellular coordination during collective keratinocyte migration.PLoS computational biology · 2024Article
- A biased random walk approach for modeling the collective chemotaxis of neural crest cells.Journal of mathematical biology · 2024Article
- Article
- Chick cranial neural crest cells release extracellular vesicles that are critical for their migration.Journal of cell science · 2022Article
- Quantitative Analysis of Directional Neural Crest Cell Migration.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Physiological electric fields induce directional migration of mammalian cranial neural crest cells.Developmental biology · 2021Article
- Modelling collective cell migration: neural crest as a model paradigm.Journal of mathematical biology · 2020Article
- Insights Into the Early Gene Regulatory Network Controlling Neural Crest and Placode Fate Choices at the Neural Border.Frontiers in physiology · 2020Review
- Embryonic Chicken (Comparative medicine · 2019Review
- Neural crest streaming as an emergent property of tissue interactions during morphogenesis.PLoS computational biology · 2019Article
- Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration.Developmental biology · 2018Article
- Neural crest and cancer: Divergent travelers on similar paths.Mechanisms of development · 2017Review
- Leaders in collective migration: are front cells really endowed with a particular set of skills?F1000Research · 2017Review
- Modelling collective cell migration of neural crest.Current opinion in cell biology · 2016Review
- Multidisciplinary approaches to understanding collective cell migration in developmental biology.Open biology · 2016Review
- Control of the collective migration of enteric neural crest cells by the Complement anaphylatoxin C3a and N-cadherin.Developmental biology · 2016Article
- Probing Leader Cells in Endothelial Collective Migration by Plasma Lithography Geometric Confinement.Scientific reports · 2016Article
- FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis.Development (Cambridge, England) · 2015Article
- Chicken trunk neural crest migration visualized with HNK1.Acta histochemica · 2015Article
- From classical to current: analyzing peripheral nervous system and spinal cord lineage and fate.Developmental biology · 2015Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Directed cell migration often involves at least two types of cell motility that include multicellular streaming and chain migration. However, what is unclear is how cell contact dynamics and the distinct microenvironments through which cells travel influence the selection of one migratory mode or the other. The embryonic and highly invasive neural crest (NC) are an excellent model system to study this question since NC cells have been observed in vivo to display both of these types of cell motility. Here, we present data from tissue transplantation experiments in chick and in silico modeling that test our hypothesis that cell contact dynamics with each other and the microenvironment promote and sustain either multicellular stream or chain migration. We show that when premigratory cranial NC cells (at the pre-otic level) are transplanted into a more caudal region in the head (at the post-otic level), cells alter their characteristic stream behavior and migrate in chains. Similarly, post-otic NC cells migrate in streams after transplantation into the pre-otic hindbrain, suggesting that local microenvironmental signals dictate the mode of NC cell migration. Simulations of an agent-based model (ABM) that integrates the NC cell behavioral data predict that chain migration critically depends on the interplay of biased cell-cell contact and local microenvironment signals. Together, this integrated modeling and experimental approach suggests new experiments and offers a powerful tool to examine mechanisms that underlie complex cell migration patterns.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.