ReviewEnvironmental health perspectives2013
Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment.
Review in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
179 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Metagenome meta-analysis reveals an increase in the abundance of some multidrug efflux pumps and mobile genetic elements in chemically polluted environments.Applied and environmental microbiology · 2023Pooled it
- One Health and Global Health View of Antimicrobial Susceptibility through the "Eye" of Aeromonas: Systematic Review and Meta-Analysis.International journal of antimicrobial agents · 2023Pooled it
- Article
- Dynamic Bacterial Communities, Resistome-Virulome Coupling, and Biomonitoring Paradigms at Direct Sea Discharge Outlets: An Integrated Microbiome Perspective for Coastal Pollution Control.Microorganisms · 2026Review
- The mobile resistome in the water-soil-air nexus: horizontal gene transfer and environmental dissemination of antimicrobial resistance genes.FEMS microbiology ecology · 2026Review
- Thermochemical Treatment of Wastewater Residual Solids for Global Mitigation of Emerging Contaminants.Nature communications · 2026Article
- Harnessing Visible Light: MXene/g‑CPrecision chemistry · 2026Article
- Genomic convergence of multidrug resistance, virulence-associated loci, and phage defense systems in Klebsiella pneumoniae from pharmaceutical wastewater in Bangladesh.Scientific reports · 2026Article
- Special Issue: "Microorganisms in the Environment".International journal of molecular sciences · 2026Article
- The Nexus of Heavy Metals and Antibiotic Resistance: Investigating Industrial Effluent-Associated Bacterial Strains.Current microbiology · 2026Article
- Antibiotic resistance dissemination in soil ecosystems: deep understanding for effective management and global health protection.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Antimicrobial redistribution: health practitioner One health perspectives on antimicrobial use in livestock for antimicrobial resistance education in Zimbabwe.JAC-antimicrobial resistance · 2026Article
- Plastics as vectors for pathogens and antibiotic resistance genes in aquatic systems.Water science and technology : a journal of the International Association on Water Pollution Research · 2026Review
- Metals and Microbes: Microbial Community Diversity and Antibiotic Resistance in the Animas River Watershed, Colorado, USA.Microorganisms · 2026Article
- Phenotypic and safety exploration of indigenous bacterial strains for probiotic applications in aquaculture.BMC microbiology · 2025Article
- A Review on the Degradation of Antibiotic Resistance Genes During Composting of Livestock Manure.Toxics · 2025Review
- The Role of the Environment (Water, Air, Soil) in the Emergence and Dissemination of Antimicrobial Resistance: A One Health Perspective.Antibiotics (Basel, Switzerland) · 2025Review
- Aquatic Resistome in Freshwater and Marine Environments: Interactions Between Commensal and Pathogenic in the Context of Aquaculture and One Health.Microorganisms · 2025Review
- Antibiotic Resistance in Aquaculture: Challenges, Trends Analysis, and Alternative Approaches.Antibiotics (Basel, Switzerland) · 2025Review
119 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is growing concern worldwide about the role of polluted soil and water environments in the development and dissemination of antibiotic resistance.
objectiveOur aim in this study was to identify management options for reducing the spread of antibiotics and antibiotic-resistance determinants via environmental pathways, with the ultimate goal of extending the useful life span of antibiotics. We also examined incentives and disincentives for action.
methodsWe focused on management options with respect to limiting agricultural sources; treatment of domestic, hospital, and industrial wastewater; and aquaculture. DISCUSSION: We identified several options, such as nutrient management, runoff control, and infrastructure upgrades. Where appropriate, a cross-section of examples from various regions of the world is provided. The importance of monitoring and validating effectiveness of management strategies is also highlighted. Finally, we describe a case study in Sweden that illustrates the critical role of communication to engage stakeholders and promote action.
conclusionsEnvironmental releases of antibiotics and antibiotic-resistant bacteria can in many cases be reduced at little or no cost. Some management options are synergistic with existing policies and goals. The anticipated benefit is an extended useful life span for current and future antibiotics. Although risk reductions are often difficult to quantify, the severity of accelerating worldwide morbidity and mortality rates associated with antibiotic resistance strongly indicate the need for action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.