Evidence map›Paper›PMID 23735116›Full record

ArticleItalian journal of pediatrics2013

Vitamin D status in cord blood and newborns: ethnic differences.

Francesco Cadario, Silvia Savastio, Erica Pozzi, Antonella Capelli, Elena Dondi, Miriam Gatto, Mauro Zaffaroni, Gianni Bona

Abstract readComparative Study
In one paragraph

Article in Italian journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Vitamin D status in very low birth weight infants and response to vitamin D intake during their NICU stays: a prospective cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Article
  9. Article
  10. Article
  11. Evaluation of vitamin DScientific reports · 2019
    Article
  12. Review
  13. Article
  14. Article
  15. Vitamin D Concentration in Maternal and Umbilical Cord Blood by Season.International journal of environmental research and public health · 2017
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Racial disparities in cord blood vitamin D levels and its association with small-for-gestational-age infants.Journal of perinatology : official journal of the California Perinatal Association · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesco CadarioDivision of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy. francesco.cadario@maggioreosp.novara.it
Silvia Savastio
Erica Pozzi
Antonella Capelli
Elena Dondi
Miriam Gatto
Mauro Zaffaroni
Gianni Bona

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA deficiency in vitamin D (25OHD) is common throughout the world in both adults and children, being related to skin pigmentation, sun exposure, dietary intake and obesity. Limited data are available for the neonatal age. The aim of the study is to understand the differences in 25OHD levels with respect to skin colour and ethnicity in newborns.

methodsWe randomly enrolled 62 neonates, born at term and appropriate for gestational age. Thirty two were born from Italian mothers with fair skin (FS) and 30 from non-Caucasian mothers (North African, African, Asian and Latin American): 10 with light olive/light brown (LOB) and 20 with medium brown/black skin (MBB). Vitamin D was measured in the cord blood at birth and in neonatal serum during metabolic screening.

results25OHD levels were (mean ± SD) 21.4 ± 11 ng/ml in cord blood and 14.9 ± 7 ng/ml in serum after birth. 25OHD values were higher in cord blood (p < 0.01) and neonatal serum (p < 0.001) in subjects supplemented with Vitamin D. Newborn FS showed higher vitamin D levels in cord blood when compared to LOB and MBB (p < 0.01), and higher levels in neonatal serum when compared to LOB (p < 0.01). In cord blood, 25OHD levels were higher in Italian newborns than in North African (p < 0.004) and African (p < 0.01). In neonatal serum, 25OHD levels were higher in Italian infants only when compared with North African infants (p < 0.03).

conclusionsThe present study shows a high prevalence of vitamin D insufficiency and deficiency in newborns with significant differences observed to be due to ethnicity, skin colour and maternal supplementation during the pregnancy.

Indexed as

Fetal BloodAsia, WesternBlack PeopleBone Density Conservation AgentsCalcifediolDietary SupplementsFemaleHispanic or LatinoHumansInfant, NewbornItalyMothersPregnancyPrevalenceVitamin D DeficiencyWhite PeopleBone Density Conservation AgentsCalcifediol

Identifiers

PMID23735116
PMCPMC3685533

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.