Trial reportAddiction (Abingdon, England)2013
Managing psychiatric comorbidity within versus outside of methadone treatment settings: a randomized and controlled evaluation.
Trial report in Addiction (Abingdon, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Health outcomes and service use patterns associated with co-located outpatient mental health care and alcohol and other drug specialist treatment: A systematic review.Drug and alcohol review · 2023Pooled it
- Psychosocial interventions for people with both severe mental illness and substance misuse.The Cochrane database of systematic reviews · 2019Pooled it
- Trial
- Comparison of methods to assess psychiatric medication adherence in methadone-maintained patients with co-occurring psychiatric disorder.Drug and alcohol dependence · 2016Trial
- Substance use and response to psychiatric treatment in methadone-treated outpatients with comorbid psychiatric disorder.Journal of substance abuse treatment · 2015Trial
- Treatment for Comorbid Mental Health Disorders Among Patients Treated for Opioid Disorder: The Role of a Hub and Spoke Intervention.Community mental health journal · 2026Article
- Retention Challenges in Opioid Use Disorder Treatment: The Role of Comorbid Psychological Conditions.The western journal of emergency medicine · 2025Article
- Strained patient-provider relationship, unmotivated workforce, financial constraints, and stigma: Multiple challenges in integrating mental health care within Vietnam's methadone clinics.Journal of ethnicity in substance abuse · 2025Article
- Observational
- Comorbid Affective and Substance Use Disorders of Medicaid/Medicare Beneficiaries at an Opioid Treatment Program Serving Small Urban and Rural Communities.Frontiers in psychiatry · 2022Article
- The Inclusion of Patients' Reported Outcomes to Inform Treatment Effectiveness Measures in Opioid Use Disorder. A Systematic Review.Patient related outcome measures · 2022Review
- Sensitivity and specificity of self-reported psychiatric diagnoses amongst patients treated for opioid use disorder.BMC psychiatry · 2021Article
- Requiring Buprenorphine Waivers for Psychiatry Residents.Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry · 2019Article
- Polydrug abuse among opioid maintenance treatment patients is related to inadequate dose of maintenance treatment medicine.BMC psychiatry · 2017Article
- The State of Opioid Agonist Therapy in Canada 20 Years after Federal Oversight.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Review
- The impact of comorbid psychiatric disorders on methadone maintenance treatment in opioid use disorder: a prospective cohort study.Neuropsychiatric disease and treatment · 2017Article
- Optimising health and safety of people who inject drugs during transition from acute to outpatient care: narrative review with clinical checklist.Postgraduate medical journal · 2016Review
- Classifying substance use disorder treatment facilities with co-located mental health services: A latent class analysis approach.Drug and alcohol dependence · 2016Article
- Effect of traumatic event reexposure and PTSD on substance use disorder treatment response.Drug and alcohol dependence · 2016Article
- Factors Associated with Symptoms of Depression among Injection Drug Users Receiving Antiretroviral Treatment in Indonesia.Journal of AIDS & clinical research · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsIntegrating psychiatric services within substance abuse treatment settings is a promising service delivery model, but has not been evaluated using random assignment to psychiatric treatment setting and controlled delivery of psychiatric care. This study evaluates the efficacy of on-site and integrated psychiatric service delivery in an opioid-agonist treatment program on psychiatric and substance use outcomes.
designParticipants at the Addiction Treatment Services (ATS) were assigned randomly to receive on-site and integrated substance abuse and psychiatric care (on-site: n = 160) versus off-site and non-integrated substance abuse and psychiatric care (off-site: n = 156), and observed for 1 year. On-site participants received all psychiatric care within the substance abuse program by the same group of treatment providers. The same type and schedule of psychiatric services were available to off-site participants at a community psychiatry program.
settingAll participants received routine methadone maintenance at the ATS program in Baltimore, Maryland, USA.
participantsParticipants were opioid-dependent men and women with at least one comorbid psychiatric disorder, as assessed by the Structured Clinical Interview for DSM-IV and confirmed by expert clinical reappraisal. MEASUREMENTS: Outcomes included psychiatric service utilization and retention, Hopkins Symptom Checklist Global Severity Index (GSI) change scores and urinalysis test results.
findingsOn-site participants were more likely to initiate psychiatric care 96.9 to 79.5%; P < 0.001), remain in treatment longer (195.9 versus 101.9 days; P < 0.001), attend more psychiatrist appointments (12.9 versus 2.7; P < 0.001) and have greater reductions in GSI scores (4.2 versus 1.7; P = 0.003) than off-site participants; no differences were observed for drug use.
conclusionsOn-site and integrated psychiatric and substance misuse services in a methadone treatment setting might improve psychiatric outcomes compared with off-site and non-integrated substance misuse and psychiatric care. However, this might not translate into improved substance misuse outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.