ArticleParasites & vectors2013
Genome-wide comparative analysis revealed significant transcriptome changes in mice after Toxoplasma gondii infection.
Article in Parasites & vectors, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Effects of latent infection of Toxoplasma gondii strains with different genotypes on mouse behavior and brain transcripts.Parasites & vectors · 2025Article
- Expression profiles of host miRNAs and circRNAs and ceRNA network during Toxoplasma gondii lytic cycle.Parasitology research · 2024Article
- Temporal transcriptomic changes in long non-coding RNAs and messenger RNAs involved in the host immune and metabolic response during Toxoplasma gondii lytic cycle.Parasites & vectors · 2022Article
- Targeted Transcriptomic Analysis of C57BL/6 and BALB/c Mice During Progressive ChronicFrontiers in cellular and infection microbiology · 2021Article
- Transcriptome Profiling ofMicroorganisms · 2020Article
- Transcriptomic Profiling of Mouse Brain During Acute and Chronic Infections byFrontiers in microbiology · 2020Article
- Metabolomic signature of mouse cerebral cortex following Toxoplasma gondii infection.Parasites & vectors · 2019Article
- Article
- Evidence for host genetic regulation of altered lipid metabolism in experimental toxoplasmosis supported with gene data mining results.PloS one · 2017Article
- Long-Term Relationships: the Complicated Interplay between the Host and the Developmental Stages of Toxoplasma gondii during Acute and Chronic Infections.Microbiology and molecular biology reviews : MMBR · 2015Review
- Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundToxoplasma gondii is an intracellular parasite that can modulate host responses and presumably host behavior. Host responses as well as pathogenesis vary depending on the parasite strains that are responsible for infection. In immune competent individuals, T. gondii preferentially infects tissues of the central nervous systems (CNS), which might be an additional factor in certain psychiatric disorders. While in immune-compromised individuals and pregnant women, the parasite can cause life-threatening infections. With the availability of the genome-wide investigation platform, the global responses in gene expression of the host after T. gondii infection can be systematically investigated.
methodsTotal RNA of brain tissues and peripheral lymphocytes of BALB/C mice infected with RH and ME 49 strain T. gondii as well as that of healthy mice were purified and converted to cRNA with incorporated Cy5-CTP (experimental samples), or Cy3-CTP (control samples). The labeled cRNA probes were hybridized to the Whole Mouse Genome Microarray. The impact of parasite infection on gene expression in both brain tissues and peripheral lymphocytes were analyzed. Differentially expressed genes were revalidated with real-time quantitative reverse transcriptase-polymerase chain reaction (Q-PCR).
resultsData indicated that the genes associated with immunity were up-regulated after infection by the two parasite strains, but significant up-regulation was observed in both brain tissues and peripheral lymphocytes of mice infected with ME49 strain compared to that infected by RH strain. The pathways related to pathogenesis of the nervous system were more significantly up-regulated in mice infected with RH strain.
conclusionsGenetically distinct T. gondii strains showed clear differences in modulation of host pathophysiological and immunological responses in both brain tissue and peripheral lymphocytes. It was likely that some of the host responses to T. gondii infection were universal, but the immune response and CNS reaction were in a strain-specific manner.
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