ArticleAddiction (Abingdon, England)2013
Deviant smooth pursuit in preschool children exposed prenatally to methadone or buprenorphine and tobacco affects integrative visuomotor capabilities.
Article in Addiction (Abingdon, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Effects of opioid use in pregnancy on pediatric development and behaviour in children older than age 2: Systematic review.Canadian family physician Medecin de famille canadien · 2019Pooled it
- Adolescent prefrontal and amygdala molecular signatures of perinatal morphine versus buprenorphine exposure in mice.Neurotoxicology · 2026Article
- Preventive Care Uptake and Long-Term Healthcare Use Among Children with Fetal Opioid Exposure in Ontario, Canada: A Population-Based Retrospective Cohort Study.International journal of population data science · 2026Article
- Children had smaller brain volumes and cortical surface areas after prenatal opioid maintenance therapy exposure.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Infant and early childhood physical health assessments in the HEALthy Brain and Child Development (HBCD) Study.Developmental cognitive neuroscience · 2024Article
- Impaired vision in children prenatally exposed to methadone: an observational cohort study.Eye (London, England) · 2024Observational
- Perinatal morphine but not buprenorphine affects gestational and offspring neurobehavioral outcomes in mice.Neurotoxicology · 2023Article
- Prenatal exposure to opioids and neurodevelopment in infancy and childhood: A systematic review.Frontiers in pediatrics · 2023Review
- Brain structural connectome in neonates with prenatal opioid exposure.Frontiers in neuroscience · 2022Article
- The immediate and long-term effects of prenatal opioid exposure.Frontiers in pediatrics · 2022Review
- Prenatal opioid exposure and vulnerability to future substance use disorders in offspring.Experimental neurology · 2021Review
- Dextromethorphan Dampens Neonatal Astrocyte Activation and Endoplasmic Reticulum Stress Induced by Prenatal Exposure to Buprenorphine.Behavioural neurology · 2021Article
- Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities.Pediatrics · 2019Review
- Will Widespread Synthetic Opioid Consumption Induce Epigenetic Consequences in Future Generations?Frontiers in pharmacology · 2018Review
- The feasibility of automated eye tracking with the Early Childhood Vigilance Test of attention in younger HIV-exposed Ugandan children.Neuropsychology · 2017Article
- Behavior and Attention Problems in Eight-Year-Old Children with Prenatal Opiate and Poly-Substance Exposure: A Longitudinal Study.PloS one · 2016Article
- Longitudinal cognitive development of children born to mothers with opioid and polysubstance use.Pediatric research · 2015Article
- Methodological Issues in Assessing the Impact of Prenatal Drug Exposure.Substance abuse : research and treatment · 2015Review
- A longitudinal study on substance use and related problems in women in opioid maintenance treatment from pregnancy to four years after giving birth.Substance abuse : research and treatment · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsAlthough an increasing number of children are born to mothers in opioid maintenance therapy (OMT), little is known about the long-term effects of these opioids. Previous studies suggest an association between prenatal OMT exposure and difficulties in eye movement control. Also, the effects of tobacco smoking on eye movements have been reported. The present study examined the influence of eye movements, i.e. smooth pursuit, on visuomotor capabilities in children of smoking mothers in OMT.
designThe study comprised a 2 (OMT versus contrast group) × 2 (slow versus fast smooth pursuit) between-subject factorial design.
settingThe cognitive developmental research unit at the University of Oslo, Norway.
participantsParticipants were 26 4-year-old children of tobacco-smoking women in OMT and 23 non-exposed 4-year-old children, with non-smoking mothers, matched by gender and age. MEASUREMENT: Eye movements and smooth pursuit were recorded using a Tobii 1750 eyetracker. Visuomotor functions were examined by Bender test.
findingsThe OMT group tracked slowly moving objects with smooth pursuit in a similar manner to their non-exposed peers. When fast smooth pursuit was measured, the OMT group of children tracked the object more slowly than the contrast group, P = 0.02, ηp(2) = 0.11. A regression analysis showed that fast smooth pursuit predicted children's performance on a visuomotor task, R(2) = 0.37.
conclusionImpaired eye-tracking skills in 4-year-old children exposed to methadone or buprenorphine and tobacco prenatally could inhibit the development of some cognitive functions in later life.
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