ArticleBMC bioinformatics2013
On the computational modeling of the innate immune system.
Article in BMC bioinformatics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Supplemented Alkaline Phosphatase Supports the Immune Response in Patients Undergoing Cardiac Surgery: Clinical and Computational Evidence.Frontiers in immunology · 2018Trial
- Multi-physiology modeling of the immune system in the era of precision immunotherapy.Frontiers in immunology · 2025Review
- Embracing complexity in sepsis.Critical care (London, England) · 2023Review
- Coupled simultaneous analysis of vaccine and self-awareness strategies on evolutionary dilemma aspect with various immunity.Heliyon · 2023Article
- Neutrophil crosstalk during cardiac wound healing after myocardial infarction.Current opinion in physiology · 2021Article
- Current and prospective computational approaches and challenges for developing COVID-19 vaccines.Advanced drug delivery reviews · 2021Review
- A Validated Mathematical Model of the Cytokine Release Syndrome in Severe COVID-19.Frontiers in molecular biosciences · 2021Article
- Dynamical analysis of SEIS model with nonlinear innate immunity and saturated treatment.European physical journal plus · 2021Article
- A Mathematical Model of the Dynamics of Cytokine Expression and Human Immune Cell Activation in Response to the PathogenFrontiers in cellular and infection microbiology · 2021Article
- Dynamic analysis of the role of innate immunity in SEIS epidemic model.European physical journal plus · 2021Article
- A personalized computational model of edema formation in myocarditis based on long-axis biventricular MRI images.BMC bioinformatics · 2019Article
- Game of neutrophils: modeling the balance between apoptosis and necrosis.BMC bioinformatics · 2019Article
- Complex Stability and an Irrevertible Transition Reverted by Peptide and Fibroblasts in a Dynamic Model of Innate Immunity.Frontiers in immunology · 2019Article
- Development of a Computational Model of Abscess Formation.Frontiers in microbiology · 2018Article
- Mathematical modeling and its analysis for instability of the immune system induced by chemotaxis.Journal of mathematical biology · 2017Article
- Physiological Dynamics in Demyelinating Diseases: Unraveling Complex Relationships through Computer Modeling.International journal of molecular sciences · 2015Review
- Computational Studies of the Intestinal Host-Microbiota Interactome.Computation (Basel, Switzerland) · 2015Article
- On the coupling of two models of the human immune response to an antigen.BioMed research international · 2014Article
- Computational modeling of microabscess formation.Computational and mathematical methods in medicine · 2012Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, there has been an increasing interest in the mathematical and computational modeling of the human immune system (HIS). Computational models of HIS dynamics may contribute to a better understanding of the relationship between complex phenomena and immune response; in addition, computational models will support the development of new drugs and therapies for different diseases. However, modeling the HIS is an extremely difficult task that demands a huge amount of work to be performed by multidisciplinary teams. In this study, our objective is to model the spatio-temporal dynamics of representative cells and molecules of the HIS during an immune response after the injection of lipopolysaccharide (LPS) into a section of tissue. LPS constitutes the cellular wall of Gram-negative bacteria, and it is a highly immunogenic molecule, which means that it has a remarkable capacity to elicit strong immune responses. We present a descriptive, mechanistic and deterministic model that is based on partial differential equations (PDE). Therefore, this model enables the understanding of how the different complex phenomena interact with structures and elements during an immune response. In addition, the model's parameters reflect physiological features of the system, which makes the model appropriate for general use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.