Trial reportPloS one2013
Obstructive sleep apnea is a predictor of abnormal glucose metabolism in chronically sleep deprived obese adults.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00261898 (Chronic Sleep Deprivation as a Risk Factor for Metabolic Syndrome and Obesity), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chronic Sleep Deprivation as a Risk Factor for Metabolic Syndrome and Obesity
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Obstructive sleep apnea, prediabetes and progression of type 2 diabetes: A systematic review and meta-analysis.Journal of diabetes investigation · 2022Pooled it
- Association between neck circumference and incidence of type 2 diabetes in Chinese adults: a longitudinal community-based study.Nutrition journal · 2026Article
- Interleukins as a potential link between obstructive sleep apnea and renal cell carcinoma.Contemporary oncology (Poznan, Poland) · 2025Review
- Association between neck circumference and diabetes mellitus: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2023Review
- Comorbidity Profile and Predictors of Obstructive Sleep Apnea Severity and Mortality in Non-Obese Obstructive Sleep Apnea Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Changes in subjective sleep quality in patients with type 2 diabetes who did not use Sleep agents: a cross-sectional study according to age and clinical background.Diabetology international · 2022Article
- Influence of Obstructive Sleep Apnea on Systemic Inflammation in Pregnancy.Frontiers in medicine · 2021Article
- Neck Circumference and 10-Year Cardiovascular Risk at the Baseline of the ELSA-Brasil Study: Difference by Sex.Arquivos brasileiros de cardiologia · 2020Article
- The Phenotype of Elderly Patients with Type 2 Diabetes Mellitus and Poor Sleep Quality.International journal of environmental research and public health · 2020Observational
- Witnessed sleep apneas together with elevated plasma glucose are predictors of COPD exacerbations.European clinical respiratory journal · 2020Article
- Epidemiological and pathophysiological evidence supporting links between obstructive sleep apnoea and Type 2 diabetes mellitus.Singapore medical journal · 2019Review
- The role of inflammation in the association between gestational diabetes and obstructive sleep apnea: A pilot study.Obstetric medicine · 2018Article
- Sleep apnea and type 2 diabetes.Journal of diabetes investigation · 2018Review
- Obesity, obstructive sleep apnea and type 2 diabetes mellitus: Epidemiology and pathophysiologic insights.Sleep medicine and disorders : international journal · 2018Article
- Neck circumference as a risk factor of screen-detected diabetes mellitus: community-based study.Diabetology & metabolic syndrome · 2016Article
- What can blood biomarkers tell us about cardiovascular risk in obstructive sleep apnea?Sleep & breathing = Schlaf & Atmung · 2015Review
- Effect of diabetes mellitus on sleep quality.World journal of diabetes · 2015Review
- Elevated neck circumference and associated factors in adolescents.BMC public health · 2015Article
- Obstructive sleep apnea risk and psychological health among non-Hispanic blacks in the Metabolic Syndrome Outcome (MetSO) cohort study.Annals of medicine · 2015Article
- Reduced systemic levels of IL-10 are associated with the severity of obstructive sleep apnea and insulin resistance in morbidly obese humans.Mediators of inflammation · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
contextSleep abnormalities, including obstructive sleep apnea (OSA), have been associated with insulin resistance.
objectiveTo determine the relationship between sleep, including OSA, and glucose parameters in a prospectively assembled cohort of chronically sleep-deprived obese subjects.
designCross-sectional evaluation of a prospective cohort study.
settingTertiary Referral Research Clinical Center.
main outcome measuresSleep duration and quality assessed by actigraphy, sleep diaries and questionnaires, OSA determined by a portable device; glucose metabolism assessed by oral glucose tolerance test (oGTT), and HbA1c concentrations in 96 obese individuals reporting sleeping less than 6.5 h on a regular basis.
resultsSixty % of subjects had an abnormal respiratory disturbance index (RDI≥5) and 44% of these subjects had abnormal oGTT results. Severity of OSA as assessed by RDI score was associated with fasting glucose (R = 0.325, p = 0.001) and fasting insulin levels (ρ = 0.217, p = 0.033). Subjects with moderate to severe OSA (RDI>15) had higher glucose concentrations at 120 min than those without OSA (RDI<5) (p = 0.017). Subjects with OSA also had significantly higher concentrations of plasma ACTH (p = 0.009). Several pro-inflammatory cytokines were higher in subjects with OSA (p<0.050). CRP levels were elevated in this sample, suggesting increased cardiovascular risk.
conclusionsOSA is associated with impaired glucose metabolism in obese, sleep deprived individuals. Since sleep apnea is common and frequently undiagnosed, health care providers should be aware of its occurrence and associated risks.
trial registrationThis study was conducted under the NIDDK protocol 06-DK-0036 and is listed in ClinicalTrials.gov NCT00261898.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.