ArticlePloS one2013
Early nutrition and weight gain in preterm newborns and the risk of retinopathy of prematurity.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Growth and Tolerance of Preterm Infants Fed a New Extensively Hydrolyzed Liquid Human Milk Fortifier.Journal of pediatric gastroenterology and nutrition · 2015Trial
- Lipidomics Reveals Circulating Lipid Biomarkers for Retinopathy of Prematurity in Preterm Infants.Ophthalmology science · 2026Article
- Parenteral nutrition use and recurrence requiring retreatment of retinopathy of prematurity after anti-VEGF monotherapy: a retrospective cohort study of preterm infants.BMC pediatrics · 2026Article
- Nutritional Management for Preterm Infants with Common Comorbidities: A Narrative Review.Nutrients · 2025Review
- Nutritional interventions to prevent retinopathy of prematurity.Pediatric research · 2024Review
- The Effects of Early Enteral and Parental Nutrition on Retinopathy of Prematurity: A Systematic Review.Cureus · 2023Review
- Blood urea nitrogen, a marker for severe retinopathy of prematurity?Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- ASSESSMENT OF NEONATAL CARE STANDARD BY THE PREDICTIVE MODEL FOR RETINOPATHY OF PREMATURITY BASED ON WEIGHT GAIN.Acta clinica Croatica · 2023Article
- Quantification of Early Neonatal Oxygen Exposure as a Risk Factor for Retinopathy of Prematurity Requiring Treatment.Ophthalmology science · 2021Article
- Preterm nutrition and neurodevelopmental outcomes.World journal of methodology · 2021Review
- Oxidative Stress in Preterm Newborns.Antioxidants (Basel, Switzerland) · 2021Review
- Metabolism in Retinopathy of Prematurity.Life (Basel, Switzerland) · 2021Review
- Systemic Factors Associated with a Thinner Choroid in Preterm Infants.Ophthalmology science · 2021Article
- Complete blood count parameters to predict retinopathy of prematurity: when to evaluate and what do they tell us?International ophthalmology · 2021Article
- Effects of nutrition therapy on growth, inflammation and metabolism in immature infants: a study protocol of a double-blind randomized controlled trial (ImNuT).BMC pediatrics · 2021Article
- Article
- Oxidative Stress Markers and the Retinopathy of Prematurity.Journal of clinical medicine · 2020Review
- Progressive Metabolic Dysfunction and Nutritional Variability Precedes Necrotizing Enterocolitis.Nutrients · 2020Article
- Late Growth and Changes in Body Composition Influence Odds of Developing Retinopathy of Prematurity among Preterm Infants.Nutrients · 2019Observational
- Simultaneous assessment of aberrant retinal vascularization, thickness, and function in an in vivo mouse oxygen-induced retinopathy model.Eye (London, England) · 2019Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo identify nutritional and weight gain limitations associated with retinopathy of prematurity (ROP) severity among very preterm newborns. PATIENTS AND
methods1180 infants <28 weeks GA at birth with ROP examination results were grouped and analyzed by quartile of weekly total calorie, carbohydrate, protein, and lipid intake, as well as growth velocity between postnatal days 7 and 28 (adjusted for GA and birth weight Z-score). ROP was categorized by development of no, mild (<prethreshold), type 2, or type 1 ROP, as well as markers of ROP severity including stage 3 ROP, zone 1 disease, and plus disease. Associations between nutritional intake and ROP severity were compared.
resultsGreater risk for Type 1 ROP (risk/95% confidence intervals) was found for infants with lowest quartile receipt of lipids (2.1/1.1, 3.8), total calories (2.2/1.4, 3.6), and carbohydrates (1.7/1.1, 2.9). Development of zone 1 ROP was associated with lipid or total calorie intake in the lowest quartile, and development of stage 3 ROP was associated with lowest quartile of total calorie intake. Growth velocity in the lowest quartile was associated with increased risk of any ROP, including type 1 ROP.
conclusionThe risk of developing severe ROP in extremely premature infants might be reduced by improving nutritional support, specifically targeting lipids and total calories, and perhaps by improving weight gain.
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