ArticleFrontiers in human neuroscience2013
The influence of APOE and TOMM40 polymorphisms on hippocampal volume and episodic memory in old age.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Functional and genetic divergence of aging-relatedFrontiers in neuroscience · 2026Pooled it
- TOMM40 genetic variants associated with healthy aging and longevity: a systematic review.BMC geriatrics · 2022Pooled it
- Genotypic Effects of the TOMM40'523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study.The journal of prevention of Alzheimer's disease · 2023Trial
- Interpretable multimodal learning for integrating neuroimaging and genetic data in Alzheimer's disease.Frontiers in radiology · 2026Article
- Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease.Acta neuropathologica communications · 2023Article
- TOMM40 '523 Genotype Distinguishes Patterns of Cognitive Improvement for Executive Function in APOEɛ3 Homozygotes.Journal of Alzheimer's disease : JAD · 2023Article
- Therapeutic considerations for APOE and TOMM40 in Alzheimers disease: A tribute to Allen Roses MD.Expert opinion on investigational drugs · 2021Article
- Cognitive Trajectories and Dementia Risk: A Comparison of Two Cognitive Reserve Measures.Frontiers in aging neuroscience · 2021Article
- DNA methylation analysis of candidate genes associated with dementia in peripheral blood.Epigenomics · 2020Article
- Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity.Brain imaging and behavior · 2020Article
- A TOMM40/APOE allele encoding APOE-E3 predicts high likelihood of late-onset Alzheimer's disease in autopsy cases.Molecular genetics & genomic medicine · 2020Article
- Cognitive impairment is correlated with insulin resistance degree: the "PA-NICO-study".Metabolic brain disease · 2017Article
- Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease.BMC medical genomics · 2017Article
- Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort.PloS one · 2017Article
- A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2017Article
- Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults.Journal of the neurological sciences · 2016Article
- The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.Neurobiology of aging · 2016Article
- Volume of the hippocampal subfields in healthy adults: differential associations with age and a pro-inflammatory genetic variant.Brain structure & function · 2015Article
- ApoE and pulse pressure interactively influence level and change in the aging of episodic memory: Protective effects among ε2 carriers.Neuropsychology · 2015Article
- Association of Alzheimer's disease GWAS loci with MRI markers of brain aging.Neurobiology of aging · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial dysfunction is implicated in neurodegenerative disorders, such as Alzheimer's disease (AD). Translocase of outer mitochondrial membrane 40 (TOMM40) may be influential in this regard by influencing mitochondrial neurotoxicity. Little is known about the influence of the TOMM40 gene on hippocampal (HC) volume and episodic memory (EM), particularly in healthy older adults. Thus, we sought to discern the influence of TOMM40 single nucleotide polymorphisms (SNPs), which have previously been associated with medial temporal lobe integrity (rs11556505 and rs2075650), on HC volume and EM. The study sample consisted of individuals from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K) who were free of dementia and known neurological disorders, and 60-87 years of age (n = 424). EM was measured by using a 16-item word list with a 2-min free recall period and delineation of the HC was performed manually. The influence of Apolipoprotein E (APOE) and TOMM40 was assessed by 2 × 2 ANOVAs and partial correlations. There was no effect of APOE and TOMM40 on EM performance and HC volume. However, partial correlations revealed that HC volume was positively associated with free recall performance (r = 0.21, p < 0.01, r (2) = 0.04). When further stratified for TOMM40, the observed association between HC volume and free recall in APOE ε4 carriers was present in combination with TOMM40 rs11556505 any T (r = 0.28, p < 0.01, R (2) = 0.08) and rs2075650 any G (r = 0.28, p < 0.01, R (2) = 0.08) "risk" alleles. This pattern might reflect higher reliance on HC volume for adequate EM performance among APOE ε4 carriers with additional TOMM40 "risk" alleles suggesting that the TOMM40 gene cannot merely be considered a marker of APOE genotype. Nevertheless, neither APOE nor TOMM40 influenced HC volume or EM in this population-based sample of cognitively intact individuals over the age of 60.
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