ArticleMolecular vision2013
Saffron administration prevents selenite-induced cataractogenesis.
Article in Molecular vision, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Pharmacological Effects of Saffron and its Constituents in Ocular Disorders from in vitro Studies to Clinical Trials: A Systematic Review.Current neuropharmacology · 2021Pooled it
- The ocular hypotensive effect of saffron extract in primary open angle glaucoma: a pilot study.BMC complementary and alternative medicine · 2014Trial
- Investigation of protective effect of carvacrol in an experimental cataract model.International ophthalmology · 2025Article
- Article
- Mucosal TLR5 activation controls healthspan and longevity.Nature communications · 2024Article
- Phytochemistry, quality control and medicinal uses of Saffron (Journal of medicine and life · 2023Review
- Saffron and Sleep Quality: A Systematic Review of Randomized Controlled Trials.Nutrition and metabolic insights · 2023Review
- Long Noncoding RNA OIP5-AS1 Promotes Cell Apoptosis and Cataract Formation by Blocking POLG Expression Under Oxidative StressInvestigative ophthalmology & visual science · 2020Article
- Current Trends in the Pharmacotherapy of Cataracts.Pharmaceuticals (Basel, Switzerland) · 2020Review
- The Preventive Effects ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Medicinal Plants and Natural Products Used in Cataract Management.Frontiers in pharmacology · 2019Review
- Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats.BMC ophthalmology · 2017Article
- Effect of Intraperitoneal Injection of Saffron on the Treatment of Experimental Endotoxin Induced Uveitis in the Rabbit.Journal of clinical and diagnostic research : JCDR · 2017Article
- Safranal and its analogs inhibit Escherichia coli ATP synthase and cell growth.International journal of biological macromolecules · 2017Article
- Inhibitory Effect of Crocin(s) on Lens α-Crystallin Glycation and Aggregation, Results in the Decrease of the Risk of Diabetic Cataract.Molecules (Basel, Switzerland) · 2016Article
- Regulatory effect of chrysin on expression of lenticular calcium transporters, calpains, and apoptotic-cascade components in selenite-induced cataract.Molecular vision · 2016Article
- Razi's Al-Hawi and saffron (Crocus sativus): a review.Iranian journal of basic medical sciences · 2015Review
- Cerebral Area Differential Redox Response of Neonatal Rats to Selenite-Induced Oxidative Stress and to Concurrent Administration of Highbush Blueberry Leaf Polyphenols.Neurochemical research · 2015Article
- Could Crocus sativus (saffron) be combined with conventional therapies for ocular diseases?Indian journal of ophthalmology · 2015Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe present study sought to investigate whether Crocus sativus stigmas (saffron) extract prevents selenium-induced cataractogenesis in vivo, and to study its possible protective mechanism.
methodsWistar rat pups were randomized into three groups. Group I (control) received subcutaneous injection of normal saline on postnatal day 10. Groups II (selenite-treated) and III (selenite+saffron-treated) received subcutaneous injection of sodium selenite (20 µmol/kg body weight) on postnatal day 10. Group III also received intraperitoneal injections of saffron extract (60 mg/kg body weight) on postnatal days 9 and 12. On postpartum day 21, rats were sacrificed and the lenses were isolated and examined for cataract formation. Activities of superoxide dismutase, glutathione peroxidase, catalase, and glutathione levels, as markers of antioxidant defense, were measured in the isolated lenses. Levels of the indicator of lipid peroxidation, malondialdehyde, and protein oxidation (sulfhydryl content) in the lens were also determined. The effect of the different treatments on lens protein profile was evaluated through an estimation of the soluble to insoluble protein ratio and sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis of the water-soluble fraction (WSF) of lens proteins.
resultsSaffron demonstrated significant protection against selenite-induced cataractogenesis in vivo. The mean activities of superoxide dismutase, glutathione peroxidase, catalase, and glutathione levels were significantly increased in group III compared to the selenite-treated group. Saffron significantly prevented selenite-induced lipid peroxidation, protein oxidation, and proteolysis and insolubilization of the lens WSF.
conclusionsSaffron extract prevented selenite-induced cataract formation in Wistar rats, possibly through the reinforcement of antioxidant status, reduction of the intensity of lipid peroxidation, protection of the sulfhydryl groups, and inhibition of proteolysis of the lens WSF. These findings highlight the anticataractogenic potential of saffron by virtue of its antioxidant property.
Indexed as
Identifiers
23734088PMC3669538W1778381470What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.