ArticleMolecular vision2013
Assessment of ultraviolet B-blocking effects of weekly disposable contact lenses on corneal surface in a mouse model.
Article in Molecular vision, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Diagnosis of Photokeratitis by Tear Ferning Using a Novel Set of SK Grading Criteria in a UVB-Induced Mouse Model.Translational vision science & technology · 2023Article
- UV light-blocking contact lenses protect against short-term UVB-induced limbal stem cell niche damage and inflammation.Scientific reports · 2018Article
- The protective effect of simvastatin against ultraviolet B-induced corneal endothelial cell death.Indian journal of ophthalmology · 2018Article
- UVB promotes the initiation of uveitic inflammatory injury in vivo and is attenuated by UV-blocking protection.Molecular vision · 2017Article
- Involvement of the extrinsic and intrinsic pathways in ultraviolet B-induced apoptosis of corneal epithelial cells.Experimental eye research · 2016Article
- Upregulation of GADD45α in light-damaged retinal pigment epithelial cells.Cell death discovery · 2016Article
- UV-blocking spectacle lens protects against UV-induced decline of visual performance.Molecular vision · 2015Article
- The TFOS International Workshop on Contact Lens Discomfort: report of the subcommittee on neurobiology.Investigative ophthalmology & visual science · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWeekly disposable soft contact lenses have been widely used recently, but their shield effects against ultraviolet (UV) irradiation remain to be evaluated. This study investigated the bioprotective effects of several weekly soft contact lenses against UVB irradiation on the corneal surface in a mouse model.
methodsFifty ICR mice were randomly divided into five groups: (1) blank control, (2) exposed to UVB without contact lens protection, (3) exposed to UVB and protected with Vifilcon A contact lenses, (4) exposed to UVB and protected with Etafilcon A contact lenses, and (5) exposed to UVB and protected with HEMA+MA contact lenses. The exposure to UVB irradiation was performed at 0.72 J/cm²)/day after anesthesia for a 7-day period, followed by cornea surface assessment for smoothness, opacity, and grading of lissamine green staining. Tissue sections were prepared for hematoxylin and eosin staining and immunohistochemical detection by using antibodies against myeloperoxidase, cytokeratin-5, P63, Ki-67, nuclear factor-kappa B (p65), cyclooxygenase-2, Fas L, and Fas.
resultsThe results showed impaired corneal surface with myeloperoxidase+ polymorphonuclear leukocyte infiltration into the stroma after UVB exposure, in contrast to the intact status of the blank controls. The corneas with Etafilcon A and HEMA+MA contact lenses maintained more cells positive for cytokeratin-5, P63, and Ki-67 compared to those with Vifilcon A or without contact lens protection. Furthermore, less proinflammatory factors, including nuclear factor-kappa (p65), cyclooxygenase-2, Fas L, and Fas, were induced in the corneas protected by Etafilcon A and HEMA+MA.
conclusionsThis study demonstrated various protective effects of weekly disposable contact lenses against UVB irradiation. The mouse model used in the present study may be used extensively for in vivo assessment of UV shield efficacy.
Indexed as
Identifiers
23734085PMC3669534W2107001194What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.