ArticleMolecular vision2013
Insulin-like growth factor 1 is not associated with high myopia in a large Japanese cohort.
Article in Molecular vision, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- The G allele of the IGF1 rs2162679 SNP is a potential protective factor for any myopia: Updated systematic review and meta-analysis.PloS one · 2022Pooled it
- Association between Insulin-Like Growth Factor 1 Gene rs12423791 or rs6214 Polymorphisms and High Myopia: A Meta-Analysis.PloS one · 2015Pooled it
- The Role of Vitamin D and Selected Nutrients in the Development of Myopia in Children and Young Adults: A Narrative Review.Journal of clinical medicine · 2026Review
- Lipid Metabolism Regulators Are the Possible Determinant for Characteristics of Myopic Human Scleral Stroma Fibroblasts (HSSFs).International journal of molecular sciences · 2023Article
- Genetic susceptibility to high myopia in Han Chinese population.Open life sciences · 2022Article
- Association ofPeerJ · 2020Article
- Update on Myopia Risk Factors and Microenvironmental Changes.Journal of ophthalmology · 2019Review
- Insight into the molecular genetics of myopia.Molecular vision · 2017Review
- Association between SCO2 mutation and extreme myopia in Japanese patients.Japanese journal of ophthalmology · 2016Article
- Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.Nature communications · 2015Article
- The association between IGF-1 polymorphisms and high myopia.International journal of clinical and experimental medicine · 2015Article
- Association study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population.Clinical ophthalmology (Auckland, N.Z.) · 2013Article
- Association study of fibroblast growth factor 10 (FGF10) polymorphisms with susceptibility to extreme myopia in a Japanese population.Molecular vision · 2013Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate whether genetic variations in the insulin-like growth factor 1 (IGF-1) gene are associated with high myopia in Japanese.
methodsA total of 1,339 unrelated Japanese patients with high myopia (axial length ≥26 mm in both eyes) and two independent control groups were evaluated (334 cataract patients without high myopia and 1,194 healthy Japanese individuals). The mean axial length (mm±SD) in the case group was 29.18±1.85 mm, and the mean spherical equivalent (D±SD) of the phakic eyes was -12.69±4.54 D. We genotyped five tagging single nucleotide polymorphisms (SNPs) in IGF-1: rs6214, rs978458, rs5742632, rs12423791, and rs2162679. Chi-square tests for trend, multivariable logistic regression, and haplotype regression analysis were conducted.
resultsWe found no significant association between the IGF-1 SNPs and high or extreme myopia (axial length ≥28 mm in both eyes, 837 subjects) in the additive model, even when compared with the cataract and general population controls, with or without adjustments for age and sex. The evaluation using dominant and recessive models also did not reveal any significant associations. The haplotype analysis with a variable-sized sliding-window strategy also showed a lack of association of IGF-1 SNPs with high or extreme myopia.
conclusionsThe results of the present study using a Japanese subset do not support the proposal that the IGF-1 gene determines susceptibility to high or extreme myopia in Caucasians and Chinese. Further studies are needed to confirm our reports in other populations and to identify the underlying genetic determinants of these ocular pathological conditions.
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Identifiers
23734076PMC3668686W2132182948What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.