ArticleProceedings of the National Academy of Sciences of the United States of America2013
Kinetics of gene derepression by ERK signaling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 57 citations in OpenAlex.
- Enhancer placement impacts transcriptional dynamics in Drosophila embryos.Nature communications · 2026Article
- ERK inhibits Capicua repressor function via multisite phosphorylation.Journal of cell science · 2026Article
- O-GlcNAc transferase congenital disorder of glycosylation (OGT-CDG): Potential mechanistic targets revealed by evaluating the OGT interactome.The Journal of biological chemistry · 2024Review
- The Role of Cyclic Adenosine Monophosphate (cAMP) in Modulating Glucocorticoid Receptor Signaling and Its Implications on Glucocorticoid-Related Collagen Loss.International journal of molecular sciences · 2023Article
- Noncanonical function of Capicua as a growth termination signal inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- A kinase translocation reporter reveals real-time dynamics of ERK activity in Drosophila.Biology open · 2022Article
- ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth.Frontiers in molecular biosciences · 2022Article
- Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry.Developmental cell · 2021Article
- Article
- Regulation of spatiotemporal limits of developmental gene expression via enhancer grammar.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua.Developmental cell · 2020Article
- Activation-induced substrate engagement in ERK signaling.Molecular biology of the cell · 2020Article
- Global shape of Toll activation is determined byProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Capicua suppresses colorectal cancer progression via repression of ETV4 expression.Cancer cell international · 2020Article
- Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors.Nature communications · 2019Article
- Signaling Dynamics Control Cell Fate in the Early Drosophila Embryo.Developmental cell · 2019Article
- Article
- A quantitative model of developmental RTK signaling.Developmental biology · 2018Review
- An information theoretic treatment of sequence-to-expression modeling.PLoS computational biology · 2018Article
- Outstanding questions in developmental ERK signaling.Development (Cambridge, England) · 2018Review
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
ERK controls gene expression in development, but mechanisms that link ERK activation to changes in transcription are not well understood. We used high-resolution analysis of signaling dynamics to study transcriptional interpretation of ERK signaling during Drosophila embryogenesis, at a stage when ERK induces transcription of intermediate neuroblasts defective (ind), a gene essential for patterning of the nerve cord. ERK induces ind by antagonizing its repression by Capicua (Cic), a transcription factor that acts as a sensor of receptor tyrosine kinases in animal development and human diseases. A recent study established that active ERK reduces the nuclear levels of Cic, but it remained unclear whether this is required for the induction of Cic target genes. We provide evidence that Cic binding sites within the regulatory DNA of ind control the spatial extent and the timing of ind expression. At the same time, we demonstrate that ERK induces ind before Cic levels in the nucleus are reduced. Based on this, we propose that ERK-dependent relief of gene repression by Cic is a two-step process, in which fast reduction of repressor activity is followed by slower changes in nuclear localization and overall protein levels. This may be a common feature of systems in which ERK induces genes by relief of transcriptional repression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.