ArticleProceedings of the National Academy of Sciences of the United States of America2013
Structure of the archaeal head-tailed virus HSTV-1 completes the HK97 fold story.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed, 96 citations in OpenAlex.
- Small viruses reveal bidirectional evolution between HK97-fold viruses and encapsulins via procapsids.Nature communications · 2026Article
- Cryo-EM structure of bacteriophage Nocturne116: insights into the architecture of c2-likeJournal of virology · 2026Article
- Dispersal pathways and infection strategies within the Global Halophilic Virome.ISME communications · 2026Article
- Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail.Science advances · 2025Article
- A Two-Component Pseudo-Icosahedral Protein Nanocompartment with Variable Shell Composition and Irregular Tiling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids.Nature communications · 2025Article
- The Structural Diversity of Encapsulin Protein Shells.Chembiochem : a European journal of chemical biology · 2024Review
- Encapsulated Ferritin-like Proteins: A Structural Perspective.Biomolecules · 2024Review
- Maturation of Viruses.Sub-cellular biochemistry · 2024Review
- Archaeal virus entry and egress.microLife · 2024Review
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- A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability.Structure (London, England : 1993) · 2023Article
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- Characterization of an archaeal virus-host system reveals massive genomic rearrangements in a laboratory strain.Frontiers in microbiology · 2023Article
- Structural characterization of the Myxococcus xanthus encapsulin and ferritin-like cargo system gives insight into its iron storage mechanism.Structure (London, England : 1993) · 2022Article
- Bacterial Nanocompartments: Structures, Functions, and Applications.Journal of bacteriology · 2022Review
- Predicting the capsid architecture of phages from metagenomic data.Computational and structural biotechnology journal · 2022Article
- The remarkable viral portal vertex: structure and a plausible model for mechanism.Current opinion in virology · 2021Review
- Diversity, taxonomy, and evolution of archaeal viruses of the class Caudoviricetes.PLoS biology · 2021Article
- High Resolution Structure of the Mature Capsid ofInternational journal of molecular sciences · 2021Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
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Abstract
It has been proposed that viruses can be divided into a small number of structure-based viral lineages. One of these lineages is exemplified by bacterial virus Hong Kong 97 (HK97), which represents the head-tailed dsDNA bacteriophages. Seemingly similar viruses also infect archaea. Here we demonstrate using genomic analysis, electron cryomicroscopy, and image reconstruction that the major coat protein fold of newly isolated archaeal Haloarcula sinaiiensis tailed virus 1 has the canonical coat protein fold of HK97. Although it has been anticipated previously, this is physical evidence that bacterial and archaeal head-tailed viruses share a common architectural principle. The HK97-like fold has previously been recognized also in herpesviruses, and this study expands the HK97-like lineage to viruses from all three domains of life. This is only the second established lineage to include archaeal, bacterial, and eukaryotic viruses. Thus, our findings support the hypothesis that the last common universal ancestor of cellular organisms was infected by a number of different viruses.
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