ArticleJournal of immunology (Baltimore, Md. : 1950)2013
FoxO1 controls effector-to-memory transition and maintenance of functional CD8 T cell memory.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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Who cites it
60 citing papers in PubMed, 94 citations in OpenAlex.
- Light Metabolically Reprograms CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1Immunity · 2025Article
- Metabolic reprogramming of CAR T cells: a new frontier in cancer immunotherapy.Frontiers in immunology · 2025Review
- Focusing on CD8Journal of experimental & clinical cancer research : CR · 2024Review
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- Tim-3 Is Not Required for Establishment of CD8+ T Cell Memory to Lymphocytic Choriomeningitis Virus.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- FOXO1 is a master regulator of CAR T memory programming.Research square · 2023Article
- Regulation of CD8Cellular & molecular immunology · 2023Review
- Vaccine adjuvant-elicited CD8Cell reports · 2023Article
- Berberine improves central memory formation of CD8Acta pharmaceutica Sinica. B · 2023Article
- Berberine governs NOTCH3/AKT signaling to enrich lung-resident memory T cells during tuberculosis.PLoS pathogens · 2023Article
- The potential role of short chain fatty acids improvingFrontiers in immunology · 2023Review
- Expression of NAC1 Restrains the Memory Formation of CD8Viruses · 2022Article
- Improving CAR T-Cell Persistence.International journal of molecular sciences · 2021Review
- E2A-regulated epigenetic landscape promotes memory CD8 T cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Diverse Roles of Akt in T cells.Immunometabolism · 2021Article
- Foxo1 Serine 209 Is a Critical Regulatory Site of CD8 T Cell Differentiation and Survival.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes.Frontiers in immunology · 2021Article
- Cellular and Molecular Mechanisms of CD8International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
During a T cell response, naive CD8 T cells differentiate into effector cells. Subsequently, a subset of effector cells termed memory precursor effector cells further differentiates into functionally mature memory CD8 T cells. The transcriptional network underlying this carefully scripted process is not well understood. In this study, we report that the transcription factor FoxO1 plays an integral role in facilitating effector-to-memory transition and functional maturation of memory CD4 and CD8 T cells. We find that FoxO1 is not required for differentiation of effector cells, but in the absence of FoxO1, memory CD8 T cells displayed features of senescence and progressive attrition in polyfunctionality, which in turn led to impaired recall responses and poor protective immunity. These data suggest that FoxO1 is essential for maintenance of functional CD8 T cell memory and protective immunity. Under competing conditions in bone marrow chimeric mice, FoxO1 deficiency did not perturb clonal expansion or effector differentiation. Instead, FoxO1-deficient memory precursor effector cells failed to survive and form memory CD8 T cells. Mechanistically, FoxO1 deficiency perturbed the memory CD8 T cell transcriptome, characterized by pronounced alterations in the expression of genes that encode transcription factors (including Tcf7), effector molecules, cell cycle regulators, and proteins that regulate fatty acid, purine, and pyramidine metabolism and mitochondrial functions. We propose that FoxO1 is a key regulator that reprograms and steers the differentiation of effector cells to functionally competent memory cells. These findings have provided fundamental insights into the mechanisms that regulate the quality of CD8 T cell memory to intracellular pathogens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.