ArticleGenetics2013
The length of the shortest telomere as the major determinant of the onset of replicative senescence.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Is there a role for traditional and complementary medicines in managing chronic fatigue? a systematic review of randomized controlled trials.Frontiers in pharmacology · 2023Pooled it
- Determinants of chromosome-specific telomere lengths among 2573 All of Us participants.Nature communications · 2026Article
- Both genome instability and replicative senescence stem from the shortest telomere in telomerase-negative cells.Nature communications · 2026Article
- Natural diversity of telomere length distributions across 100Genome research · 2026Article
- Telomeres in skin aging.Biogerontology · 2025Review
- Telomere Dynamics in Post-Traumatic Stress Disorder: A Critical Synthesis.Biomedicines · 2025Review
- Mathematical model linking telomeres to senescence in Saccharomyces cerevisiae reveals cell lineage versus population dynamics.Nature communications · 2025Article
- Insights into the length and breadth of methodologies harnessed to study human telomeres.Biomarker research · 2024Article
- ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop reader.Protein & cell · 2024Article
- Directional selection, not the direction of selection, affects telomere length and copy number at ribosomal RNA loci.Scientific reports · 2024Article
- Characterization of telomere variant repeats using long reads enables allele-specific telomere length estimation.BMC bioinformatics · 2024Article
- TERRA and Telomere Maintenance in the YeastGenes · 2023Review
- The multistep path to replicative senescence onset: zooming on triggering and inhibitory events at telomeric DNA.Frontiers in cell and developmental biology · 2023Review
- Placental telomere length shortening is not associated with severe preeclampsia but the gestational age.Aging · 2022Article
- Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing.Genome research · 2022Article
- Article
- Real-life prevalence of progressive fibrosing interstitial lung diseases.Scientific reports · 2021Article
- Telomere shortening causes distinct cell division regimes during replicative senescence in Saccharomyces cerevisiae.Cell & bioscience · 2021Article
- Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length.GeroScience · 2021Article
- Method comparison studies of telomere length measurement using qPCR approaches: A critical appraisal of the literature.PloS one · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The absence of telomerase in many eukaryotes leads to the gradual shortening of telomeres, causing replicative senescence. In humans, this proliferation barrier constitutes a tumor suppressor mechanism and may be involved in cellular aging. Yet the heterogeneity of the senescence phenotype has hindered the understanding of its onset. Here we investigated the regulation of telomere length and its control of senescence heterogeneity. Because the length of the shortest telomeres can potentially regulate cell fate, we focus on their dynamics in Saccharomyces cerevisiae. We developed a stochastic model of telomere dynamics built on the protein-counting model, where an increasing number of protein-bound telomeric repeats shift telomeres into a nonextendable state by telomerase. Using numerical simulations, we found that the length of the shortest telomere is well separated from the length of the others, suggesting a prominent role in triggering senescence. We evaluated this possibility using classical genetic analyses of tetrads, combined with a quantitative and sensitive assay for senescence. In contrast to mitosis of telomerase-negative cells, which produces two cells with identical senescence onset, meiosis is able to segregate a determinant of senescence onset among the telomerase-negative spores. The frequency of such segregation is in accordance with this determinant being the length of the shortest telomere. Taken together, our results substantiate the length of the shortest telomere as being the key genetic marker determining senescence onset in S. cerevisiae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.