ArticleAntimicrobial agents and chemotherapy2013
Cell wall perturbation sensitizes fungi to the antimalarial drug chloroquine.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
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- The Antifungal and Antibiofilm Activities of Caffeine againstBiomedicines · 2022Article
- The NPR/Hal family of protein kinases in yeasts: biological role, phylogeny and regulation under environmental challenges.Computational and structural biotechnology journal · 2022Review
- Effective Treatment of Cutaneous Mold Infections by Antimicrobial Blue Light That Is Potentiated by Quinine.The Journal of infectious diseases · 2021Article
- Quinine Improves the Fungicidal Effects of Antimicrobial Blue Light: Implications for the Treatment of Cutaneous Candidiasis.Lasers in surgery and medicine · 2020Article
- The Preservative Sorbic Acid Targets Respiration, Explaining the Resistance of Fermentative Spoilage Yeast Species.mSphere · 2020Article
- Quinine Enhances Photo-Inactivation of Gram-Negative Bacteria.The Journal of infectious diseases · 2020Article
- Novel tool to quantify cell wall porosity relates wall structure to cell growth and drug uptake.The Journal of cell biology · 2019Article
- Heterologous Expression of a Novel Drug Transporter from the Malaria Parasite Alters Resistance to Quinoline Antimalarials.Scientific reports · 2018Article
- Novel Combinations of Agents Targeting Translation That Synergistically Inhibit Fungal Pathogens.Frontiers in microbiology · 2018Article
- Identification of Genes in Candida glabrata Conferring Altered Responses to Caspofungin, a Cell Wall Synthesis Inhibitor.G3 (Bethesda, Md.) · 2016Article
- Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans.PloS one · 2016Article
- Novel, Synergistic Antifungal Combinations that Target Translation Fidelity.Scientific reports · 2015Article
- Synergistic activity of chloroquine with fluconazole against fluconazole-resistant isolates of Candida species.Antimicrobial agents and chemotherapy · 2015Article
- Signaling of chloroquine-induced stress in the yeast Saccharomyces cerevisiae requires the Hog1 and Slt2 mitogen-activated protein kinase pathways.Antimicrobial agents and chemotherapy · 2014Article
- Functional toxicology: tools to advance the future of toxicity testing.Frontiers in genetics · 2014Review
- Reply to "chloroquine, an antifungal but also a fertility drug".Antimicrobial agents and chemotherapy · 2013Article
- Chloroquine, an antifungal but also a fertility drug.Antimicrobial agents and chemotherapy · 2013Article
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6 authors at 4 institutions in 2 countries.
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Abstract
Chloroquine (CQ) has been a mainstay of antimalarial drug treatment for several decades. Additional therapeutic actions of CQ have been described, including some reports of fungal inhibition. Here we investigated the action of CQ in fungi, including the yeast model Saccharomyces cerevisiae. A genomewide yeast deletion strain collection was screened against CQ, revealing that bck1Δ and slt2Δ mutants of the cell wall integrity pathway are CQ hypersensitive. This phenotype was rescued with sorbitol, consistent with cell wall involvement. The cell wall-targeting agent caffeine caused hypersensitivity to CQ, as did cell wall perturbation by sonication. The phenotypes were not caused by CQ-induced changes to cell wall components. Instead, CQ accumulated to higher levels in cells with perturbed cell walls: CQ uptake was 2- to 3-fold greater in bck1Δ and slt2Δ mutants than in wild-type yeast. CQ toxicity was synergistic with that of the major cell wall-targeting antifungal drug, caspofungin. The MIC of caspofungin against the yeast pathogen Candida albicans was decreased 2-fold by 250 μM CQ and up to 8-fold at higher CQ concentrations. Similar effects were seen in Candida glabrata and Aspergillus fumigatus. The results show that the cell wall is critical for CQ resistance in fungi and suggest that combination treatments with cell wall-targeting drugs could have potential for antifungal treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.