ArticleNeuro-oncology2013
Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis.
Article in Neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Telomere length and risk of glioma.Cancer epidemiology · 2013Trial
- DNA copy number patterns reveal prognostic markers and elucidate mechanisms of evolution in IDH-mutant astrocytoma.Neuro-oncology · 2026Article
- Relationship between genetically determined telomere length and childhood glioma risk.Acta neuropathologica communications · 2026Article
- Recursive partitioning analysis for survival stratification and early imaging prediction of molecular biomarker in glioma patients.BMC cancer · 2024Article
- Inherited genetics of adult diffuse glioma and polygenic risk scores-a review.Neuro-oncology practice · 2022Review
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- Association ofPharmacogenomics and personalized medicine · 2021Article
- Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.Acta neuropathologica communications · 2020Article
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- Clinical Significance of Various Classification Standards of Age Groups in Predicting Survival of Patients with Glioblastoma.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics.International journal of cancer · 2020Article
- Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.International journal of cancer · 2018Article
- Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017Article
- Global incidence of malignant brain and other central nervous system tumors by histology, 2003-2007.Neuro-oncology · 2017Article
- Classification based on mutations of TERT promoter and IDH characterizes subtypes in grade II/III gliomas.Neuro-oncology · 2016Article
- Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Article
- IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation.Scientific reports · 2016Article
- Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.Carcinogenesis · 2016Article
- Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.Oncotarget · 2015Article
Corrections and comments
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Authors and funding
25 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundGenome-wide association studies have implicated single nucleotide polymorphisms (SNPs) in 7 genes as glioma risk factors, including 2 (TERT, RTEL1) involved in telomerase structure/function. We examined associations of these 7 established glioma risk loci with age at diagnosis among patients with glioma.
methodsSNP genotype data were available for 2286 Caucasian glioma patients from the University of California, San Francisco (n = 1434) and the Mayo Clinic (n = 852). Regression analyses were performed to test for associations between "number of risk alleles" and "age at diagnosis," adjusted for sex and study site and stratified by tumor grade/histology where appropriate.
resultsFour SNPs were significantly associated with age at diagnosis. Carrying a greater number of risk alleles at rs55705857 (CCDC26) and at rs498872 (PHLDB1) was associated with younger age at diagnosis (P = 1.4 × 10(-22) and P = 9.5 × 10(-7), respectively). These SNPs are stronger risk factors for oligodendroglial tumors, which tend to occur in younger patients, and their association with age at diagnosis varied across tumor subtypes. In contrast, carrying more risk alleles at rs2736100 (TERT) and at rs6010620 (RTEL1) was associated with older age at diagnosis (P = 6.2 × 10(-4) and P = 2.5 × 10(-4), respectively). These SNPs are risk factors for all glioma grades/histologies, and their association with age at diagnosis was consistent across tumor subgroups.
conclusionsCarrying a greater number of risk alleles might be expected to decrease age at diagnosis. However, glioma susceptibility conferred by variation in telomerase-related genes did not follow this pattern. This supports the hypothesis that telomerase-related mechanisms of telomere maintenance are more associated with gliomas that develop later in life than those utilizing telomerase-independent mechanisms (ie, alternative lengthening of telomeres).
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