ArticleMolecular biology and evolution2013
The evolutionary history of Plasmodium vivax as inferred from mitochondrial genomes: parasite genetic diversity in the Americas.
Article in Molecular biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.
- Geographical variation in Plasmodium vivax relapse.Malaria journal · 2014Pooled it
- The monophyly of Nycteria and Polychromophilus parasites: a missing piece in the evolution of malaria and other Haemosporida.Malaria journal · 2026Article
- New Evidence of TLR4 and TLR9 Variants Influencing Parasitaemia and Symptoms of Plasmodium vivax Infection.International journal of immunogenetics · 2025Article
- Human migrations, anthropogenic changes, and insect-borne diseases in Latin America.Parasites & vectors · 2025Review
- Overview ofComparative medicine · 2024Review
- Plasmodium vivax genomic surveillance in the Peruvian Amazon with Pv AmpliSeq assay.PLoS neglected tropical diseases · 2024Article
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- A new long-read mitochondrial-genome protocol (PacBio HiFi) for haemosporidian parasites: a tool for population and biodiversity studies.Malaria journal · 2024Article
- Population genomic evidence of structured and connectedEcology and evolution · 2024Article
- Geographical origin of Plasmodium vivax in the Hainan Island, China: insights from mitochondrial genome.Malaria journal · 2023Article
- Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines.Cellular and molecular life sciences : CMLS · 2023Article
- Evolutionary history of Plasmodium vivax and Plasmodium simium in the Americas.Malaria journal · 2022Review
- Why Plasmodium vivax and Plasmodium falciparum are so different? A tale of two clades and their species diversities.Malaria journal · 2022Review
- Evolutionary history of orangutan plasmodia revealed by phylogenetic analysis of complete mtDNA genomes and new biogeographical divergence dating calibration models.American journal of primatology · 2022Article
- Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis.Heliyon · 2022Article
- Review
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- A Mitochondria-Penetrating Peptide Exerts Potent Anti-Plasmodium Activity and Localizes at Parasites' Mitochondria.Antibiotics (Basel, Switzerland) · 2021Article
- Phylogeography and population differentiation in Hepatozoon canis (Apicomplexa: Hepatozoidae) reveal expansion and gene flow in world populations.Parasites & vectors · 2021Article
- Genetic diversity in two leading Plasmodium vivax malaria vaccine candidates AMA1 and MSP119 at three sites in India.PLoS neglected tropical diseases · 2021Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 14 institutions in 9 countries.
Funding
Abstract
Plasmodium vivax is the most prevalent human malaria parasite in the Americas. Previous studies have contrasted the genetic diversity of parasite populations in the Americas with those in Asia and Oceania, concluding that New World populations exhibit low genetic diversity consistent with a recent introduction. Here we used an expanded sample of complete mitochondrial genome sequences to investigate the diversity of P. vivax in the Americas as well as in other continental populations. We show that the diversity of P. vivax in the Americas is comparable to that in Asia and Oceania, and we identify several divergent clades circulating in South America that may have resulted from independent introductions. In particular, we show that several haplotypes sampled in Venezuela and northeastern Brazil belong to a clade that diverged from the other P. vivax lineages at least 30,000 years ago, albeit not necessarily in the Americas. We propose that, unlike in Asia where human migration increases local genetic diversity, the combined effects of the geographical structure and the low incidence of vivax malaria in the Americas has resulted in patterns of low local but high regional genetic diversity. This could explain previous views that P. vivax in the Americas has low genetic diversity because these were based on studies carried out in limited areas. Further elucidation of the complex geographical pattern of P. vivax variation will be important both for diversity assessments of genes encoding candidate vaccine antigens and in the formulation of control and surveillance measures aimed at malaria elimination.
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