ReviewHuman vaccines & immunotherapeutics2013
Potential therapeutic anti-tumor effect of a Salmonella-based vaccine.
Review in Human vaccines & immunotherapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Engineering Salmonella as an immune-metabolic modulator of the tumor microenvironment.Trends in biotechnology · 2026Review
- Tumor-targeted delivery of lnc antisense RNA against RCAS1 by live-attenuated tryptophan-auxotrophicMolecular therapy. Nucleic acids · 2023Article
- Bacterial Drug Delivery Systems for Cancer Therapy: "Why" and "How".Pharmaceutics · 2023Review
- Recombinant AttenuatedCancers · 2022Review
- The Evolution and Future of Targeted Cancer Therapy: From Nanoparticles, Oncolytic Viruses, and Oncolytic Bacteria to the Treatment of Solid Tumors.Nanomaterials (Basel, Switzerland) · 2021Review
- Synergistic effects of arsenic trioxide combined withJournal of gastrointestinal oncology · 2021Article
- Integration ofCancers · 2021Review
- Heat KilledJournal of oncology · 2021Article
- Perspectives on OncolyticFrontiers in immunology · 2021Review
- Heat-killedThe Journal of international medical research · 2020Article
- Article
- Salmonella Bacterial Monotherapy Reduces Autochthonous Prostate Tumor Burden in the TRAMP Mouse Model.PloS one · 2016Article
- Myeloid-derived suppressor cells in inflammatory bowel disease.Intestinal research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the major obstacles to achieving complete eradication of tumors, even in the presence of circulating tumor-specific immunity, is the tumor-induced immunosuppressive environment, which includes myeloid-derived suppressor cells and regulatory T cells. Attenuated microorganisms have emerged as candidates for a novel anti-cancer approach in which they enhance anti-cancer immunity by boosting the innate immune system. Herein, we will discuss current innate-immunity activating strategies for anti-cancer therapy, with a focus on our recently reported approach involving the use of intratumoral injection of recombinant attenuated Salmonella enterica serovar Typhimurium vaccine; this approach elicits transformation of immunosuppressive myeloid-derived suppressor cells into TNF-α-secreting cells with characteristics of neutrophils, and reduces the generation of regulatory T cells, particularly in the presence of tumor-specific cytotoxic T lymphocytes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.