ArticleJournal of biomedical optics2013
Accuracy of retinal oximetry: a Monte Carlo investigation.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Quantifying retinal oxygenation and metabolism by phosphorescence lifetime imaging.Experimental eye research · 2025Review
- Monte-Carlo simulation and tissue-phantom model for validation of ocular oximetry.Biomedical optics express · 2022Article
- In-vivo functional and structural retinal imaging using multiwavelength photoacoustic remote sensing microscopy.Scientific reports · 2022Article
- Advances in Retinal Oximetry.Translational vision science & technology · 2021Review
- Convolutional Neural Networks for Spectroscopic Analysis in Retinal Oximetry.Scientific reports · 2019Article
- Approach for a Clinically Useful Comprehensive Classification of Vascular and Neural Aspects of Diabetic Retinal Disease.Investigative ophthalmology & visual science · 2018Article
- Visible-light optical coherence tomography: a review.Journal of biomedical optics · 2017Review
- Snapshot hyperspectral retinal imaging using compact spectral resolving detector array.Journal of biophotonics · 2017Article
- Retinal oxygen: from animals to humans.Progress in retinal and eye research · 2017Review
- Bayer Filter Snapshot Hyperspectral Fundus Camera for Human Retinal Imaging.Current eye research · 2017Article
- Retinal oximetry in humans using visible-light optical coherence tomography [Invited].Biomedical optics express · 2017Article
- Increased Retinal Oxygen Metabolism Precedes Microvascular Alterations in Type 1 Diabetic Mice.Investigative ophthalmology & visual science · 2017Article
- Photoacoustic imaging of the eye: A mini review.Photoacoustics · 2016Review
- Retinal oxygen extraction in humans.Scientific reports · 2015Article
- Monte Carlo investigation on quantifying the retinal pigment epithelium melanin concentration by photoacoustic ophthalmoscopy.Journal of biomedical optics · 2015Article
- Monte Carlo Investigation of Optical Coherence Tomography Retinal Oximetry.IEEE transactions on bio-medical engineering · 2015Article
- A combined method to quantify the retinal metabolic rate of oxygen using photoacoustic ophthalmoscopy and optical coherence tomography.Scientific reports · 2014Article
- Fundus camera guided photoacoustic ophthalmoscopy.Current eye research · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Retinal hemoglobin oxygen saturation (sO2) level is believed to be associated with the pathophysiology of several leading blinding diseases. Methods to properly measure retinal sO2 have been investigated for decades; however, the accuracy of retinal oximetry is still considered to be limited. The Monte Carlo simulation of photon transport in retina to examine how the accuracy of retinal oximetry is affected by local parameters is discussed. Fundus photography was simulated in a multilayer retinal model, in which a single vessel segment with 0.7 sO2 was embedded, at six optical wavelengths. Then, 200 million photons were traced in each simulation to ensure statistically stable results. The optical reflectance and energy deposit were recorded to measure sO2 using both the reflection method (existing retinal oximetry) and a new absorption method, photoacoustic ophthalmoscopy (PAOM). By varying the vessel diameter and melanin concentration in the retinal pigment epithelium, the relative error of sO2 measurement in the reflection method increased with increasing vessel diameter and melanin concentration; in comparison, the sO2 measurement was insensitive to these two parameters in PAOM. The results suggest that PAOM potentially can be a more accurate tool in quantifying retinal sO2.
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Registered trials
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