ArticlePediatric research2013
Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase.
Article in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- SN2-Palmitate Reduces Fatty Acid Excretion in Chinese Formula-fed Infants.Journal of pediatric gastroenterology and nutrition · 2016Trial
- Characterization of a PNLIP variant identified in Amish pediatric patients with congenital pancreatic lipase deficiency.Journal of lipid research · 2025Article
- Pancreatic lipase-related protein 2 is selectively expressed by peritubular myoid cells in the murine testis and sustains long-term spermatogenesis.Cellular and molecular life sciences : CMLS · 2023Article
- Roles of Milk Fat Globule Membrane on Fat Digestion and Infant Nutrition.Food science of animal resources · 2022Review
- Structure and Function of Pancreatic Lipase-Related Protein 2 and Its Relationship With Pathological States.Frontiers in genetics · 2021Review
- The Molecular Effects of Dietary Acid Load on Metabolic Disease (The Cellular PasaDoble: The Fast-Paced Dance of pH Regulation).Frontiers in molecular medicine · 2021Review
- Combined Approach of Cyclodextrin Complexationand Nanostructured Lipid Carriers for the Development of a Pediatric Liquid Oral Dosage Form of Hydrochlorothiazide.Pharmaceutics · 2018Article
- Article
- Influence of PEGylation of Vitamin-K-Loaded Mixed Micelles on the Uptake by and Transport through Caco-2 Cells.Molecular pharmaceutics · 2018Article
- Pathogenicity-associated protein domains: The fiercely-conserved evolutionary signatures.Gene reports · 2017Review
- Role of the gut in modulating lipoprotein metabolism.Current cardiology reports · 2014Review
- Porcine pancreatic lipase related protein 2 has high triglyceride lipase activity in the absence of colipase.Biochimica et biophysica acta · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDietary fats must be digested into fatty acids and monoacylglycerols prior to absorption. In adults, colipase-dependent pancreatic triglyceride lipase (PTL) contributes significantly to fat digestion. In newborn rodents and humans, the pancreas expresses low levels of PTL. In rodents, a homologue of PTL, pancreatic lipase-related protein 2 (PLRP2), and carboxyl ester lipase (CEL) compensate for the lack of PTL. In human newborns, the role of PLRP2 in dietary fat digestion is unclear. To clarify the potential of human PLRP2 to influence dietary fat digestion in newborns, we determined PLRP2 activity against human milk and infant formula.
methodsThe activity of purified recombinant PLRP2, gastric lipase (GL), and CEL against fats in human milk and formula was measured with each lipase alone and in combination with a standard pH-stat assay.
resultsColipase added to human milk stimulated fat digestion. PLRP2 and CEL had activity against human milk and formula. Predigestion with GL increased PLRP2 activity against both substrates. Together, CEL and PLRP2 activity was additive with formula and synergistic with human milk.
conclusionPLRP2 can digest fats in human milk and formula. PLRP2 acts in concert with CEL and GL to digest fats in human milk in vitro.
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Registered trials
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