ArticleEuropean radiology2013
An optimised patient-specific approach to administration of contrast agent for CT pulmonary angiography.
Article in European radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Minimizing contrast media dose in CT pulmonary angiography with high-pitch technique.The British journal of radiology · 2020Trial
- Feasibility of reducing radiation dose and contrast dose while improving image quality in dual-energy CT pulmonary angiography : Use of low-energy virtual monochromatic images with deep learning image reconstruction algorithm.Radiologie (Heidelberg, Germany) · 2026Article
- The Diverse Utility of Contrast Media Delivery and Dosing During Computed Tomography: An International Assessment of Knowledge and Practices.Current radiopharmaceuticals · 2024Article
- Impact of various iodine concentrations of iohexol and iodixanol contrast media on image reconstruction techniques in a vascular-specific contrast media phantom: quantitative and qualitative image quality assessment.La Radiologia medica · 2021Article
- CT angiography for pulmonary embolism in the emergency department: investigation of a protocol by 20 ml of high-concentration contrast medium.La Radiologia medica · 2020Article
- Ultra-low dose contrast CT pulmonary angiography in oncology patients using a high-pitch helical dual-source technology.Diagnostic and interventional radiology (Ankara, Turkey) · 2019Article
- Split-bolus contrast injection protocol enhances the visualization of the thoracic vasculature and reduced radiation dose during chest CT.The British journal of radiology · 2018Article
- Article
- Computed tomography of acute pulmonary embolism: state-of-the-art.European radiology · 2015Review
- MDCT Venography Evaluation of a Rare Collateral Vein Draining from the Left Subclavian Vein to the Great Cardiac Vein.Journal of clinical imaging science · 2014Article
- Contrast medium administration and image acquisition parameters in renal CT angiography: what radiologists need to know.Diagnostic and interventional radiology (Ankara, Turkey)Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate pulmonary vasculature opacification during CTPA using an optimised patient-specific protocol for administering contrast agent.
methodsCTPA was performed on 200 patients with suspected PE. Patients were assigned to two protocol groups: protocol A, fixed 80 ml contrast agent; protocol B used a patient-specific approach. The mean cross-sectional opacification profile of 8 central and 11 peripheral pulmonary arteries and veins was measured and the arteriovenous contrast ratio (AVCR) calculated. Protocols were compared using Mann-Whitney U non-parametric statistics. Jack-knife alternative free-response receiver-operating characteristic (JAFROC) analyses assessed diagnostic efficacy. Interobserver variations were investigated using kappa methods.
resultsA number of pulmonary arteries demonstrated increases in opacification (P < 0.03) for protocol B compared to A, whilst opacification in the heart and veins was reduced in protocol B (P = 0.05). Increased AVCR in protocol B compared with A was observed at all anatomic locations (P < 0.0002). Increased JAFROC (P < 0.0002) and kappa variation were observed with protocol B (κ = 0.78) compared to A (κ = 0.25). Mean contrast volume was reduced in protocol B (33 ± 9 ml) compared to A (80 ± 1 ml).
conclusionsSignificant improvements in visualisation of the pulmonary vasculature can be achieved with a low volume of contrast agent using injection timing based on a patient-specific contrast formula. KEY POINTS: • Optimal opacification of the pulmonary arteries is essential for CT pulmonary angiography. • Matching timing with vessel dynamics significantly improves vessel opacification. • This leads to increased arterial opacification and reduced venous opacification. • This can also lead to a reduced volume of contrast agent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.