ArticleThe journal of nutrition, health & aging2013
Elevated homocysteine levels are associated with low muscle strength and functional limitations in older persons.
Article in The journal of nutrition, health & aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed.
- A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study.Calcified tissue international · 2016Trial
- Homocysteine and the methylenetetrahydrofolate reductase 677C-->T polymorphism in relation to muscle mass and strength, physical performance and postural sway.European journal of clinical nutrition · 2013Trial
- Prospective Associations of Serum Vitamin B12, Homocysteine, and Ferritin Levels with Probable Sarcopenia.Nutrients · 2026Article
- Identifying risk factors for sarcopenia using machine learning: insights from multimodal data.European geriatric medicine · 2025Article
- Vitamin B12 status and skeletal muscle function among elderly: A literature review and pilot study on the effect of oral vitamin B12 supplementation in improving muscle function.Aging medicine (Milton (N.S.W)) · 2024Article
- Associations of serum vitamin B12 and its biomarkers with musculoskeletal health in middle-aged and older adults.Frontiers in endocrinology · 2024Article
- Sarcopenia in chronic kidney disease: from bench to bedside.The Korean journal of internal medicine · 2023Review
- Associations between Serum Folate Concentrations and Functional Disability in Older Adults.Antioxidants (Basel, Switzerland) · 2023Article
- Article
- The association between hyperkyphosis and fall incidence among community-dwelling older adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Article
- Homocysteine, Folic Acid, Cyanocobalamin, and Frailty in Older People: Findings From the "Invece. Ab" Study.Frontiers in physiology · 2021Article
- Changes and Risk Factors of Skeletal Muscle Mass and Strength in Patients with Type 2 Diabetes over 60 Years Old: A Cross-Sectional Study from China.Journal of diabetes research · 2020Observational
- Pilot Study on Genetic Associations With Age-Related Sarcopenia.Frontiers in genetics · 2020Article
- Genetic Variants of Homocysteine Metabolism, Homocysteine, and Frailty - Rugao Longevity and Ageing Study.The journal of nutrition, health & aging · 2020Article
- Restoration of skeletal muscle homeostasis by hydrogen sulfide during hyperhomocysteinemia-mediated oxidative/ER stress conditionCanadian journal of physiology and pharmacology · 2019Review
- Low Levels of Branched Chain Amino Acids, Eicosapentaenoic Acid and Micronutrients Are Associated with Low Muscle Mass, Strength and Function in Community-Dwelling Older Adults.The journal of nutrition, health & aging · 2019Article
- Hyperhomocysteinemia Associated with Low Muscle Mass, Muscle Function in Elderly Hemodialysis Patients: An Analysis of Multiple Dialysis Centers.BioMed research international · 2019Article
- Relationship between Homocysteine and Muscle Strength Decline: The Baltimore Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Exercise mitigates the effects of hyperhomocysteinemia on adverse muscle remodeling.Physiological reports · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe current study aimed to examine homocysteine in relation to different aspects of physical functioning. DESIGN, SETTING AND
participantsCross-sectional and longitudinal data (3-years follow-up) from the Longitudinal Aging Study Amsterdam (LASA) were used. The study was performed in persons aged ≥ 65 years (N= 1301 after imputation). MEASUREMENTS: Different measures of physical functioning, including muscle mass, grip strength, functional limitations, and falling were regarded as outcomes. Gender and serum creatinine level were investigated as effect modifiers.
resultsResults were stratified by gender. In men, higher homocysteine levels were associated with lower grip strength (Quartile 4: regression coefficient (B)= -3.07 (-4.91; -1.22)), and more functional limitations at baseline (Quartile 4: B= 1.15 (0.16-2.14)). In women, higher homocysteine levels were associated with more functional limitations after 3 years (Quartile 4: B= 1.19 (0.25; 2.13)). Higher homocysteine levels were not associated with low muscle mass or falling.
conclusionsThese data suggest an inverse association of homocysteine levels with functional limitations in older men and women, and with muscle strength in older men.
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Registered trials
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