Evidence map›Paper›PMID 23732551›Full record

Trial reportThe journal of nutrition, health & aging2013

Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial.

E H Martínez-Lapiscina, P Clavero, E Toledo, B San Julián, A Sanchez-Tainta, D Corella, R M Lamuela-Raventós, J A Martínez, M Á Martínez-Gonzalez

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of nutrition, health & aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03978052 (Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention), which is not on this map. Cited by 118 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 17 pooled it
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03978052 nacompletednot on this mapstarted 2019, after this paper: background citation

Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention

TypeinterventionalSponsorParc de Salut MarRan2019 to 2023Enrolled129ConditionsAlzheimer Disease, Cognitive DeclineArmsEGCG, Placebo EGCG, Healthy lifestyle recommendations, Multimodal lifestyle intervention
3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 17 syntheses or guidelines pooled it, 262 citations in OpenAlex.

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  5. Nut Consumption for Cognitive Performance: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2021
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  6. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
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  7. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
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  15. Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis.Climacteric : the journal of the International Menopause Society · 2015
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

E H Martínez-LapiscinaDepartamento de Medicina Preventiva y Salud Pública, Facultad de Medicina-Clínica Universidad de Navarra, Universidad de Navarra, C/ Irunlarrea n1 1, Pamplona, Navarra, E-31008, Spain. elenahmlapiscina@gmail.com
P Clavero
E Toledo
B San Julián
A Sanchez-Tainta
D Corella
R M Lamuela-Raventós
J A Martínez
M Á Martínez-Gonzalez
Universidad de Navarra · ESInstituto de Salud Carlos III · ESComplejo Hospitalario de Navarra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the effect on cognition of a controlled intervention testing Mediterranean diets (MedDiet).

designRandomized trial after 6.5 years of nutritional intervention.

settingEight primary care centers affiliated to the University of Navarra.

participantsA random subsample of 285 participants (95 randomly allocated to each of 3 groups) of the PREDIMED-NAVARRA trial. All of them were at high vascular risk (44.8% men, 74.1±5.7 years at cognitive evaluation).

interventionsNutritional intervention comparing two MedDiets (supplemented with extra-virgin olive oil [EVOO] or mixed nuts) versus a low-fat control diet. Participants received intensive education to increase adherence to the intended intervention. Participants allocated to the MedDiet groups received EVOO (1 l/week) or 30 g/day of mixed nuts. Dietary habits were evaluated using a validated 137-item food frequency questionnaire (FFQ). Additionally, adherence to MedDiet was appraised using a 14-item questionnaire both at baseline and yearly thereafter. MEASUREMENTS: Cognitive performance as a main outcome and cognitive status (normal, mild cognitive impairment [MCI] or dementia) as a secondary outcome were evaluated by two neurologists blinded to group assignment after 6.5 years of nutritional intervention.

resultsBetter post-trial cognitive performance versus control in all cognitive domains and significantly better performance across fluency and memory tasks were observed for participants allocated to the MedDiet+EVOO group. After adjustment for sex, age, education, apolipoprotein E genotype, family history of cognitive impairment/dementia, smoking, physical activity, body mass index, hypertension, dyslipidaemia, diabetes, alcohol and total energy intake, this group also showed lower MCI (OR=0.34 95% CI: 0.12-0.97) compared with control group. Participants assigned to MedDiet+Nuts group did not differ from controls.

conclusionA long-term intervention with an EVOO-rich MedDiet resulted in a better cognitive function in comparison with a control diet. However, non-significant differences were found for most cognitive domains. Participants allocated to an EVOO-rich MedDiet had less MCI than controls.

Indexed as

Dietary SupplementsAgedAged, 80 and overBody Mass IndexCognitionCognitive DysfunctionDementiaDiet, Fat-RestrictedDiet, MediterraneanEnergy IntakeFeeding BehaviorFemaleFollow-Up StudiesHumansLogistic ModelsMaleOlive OilPlant Oils

Identifiers

PMID23732551
PMCPMC12878917
OpenAlexW1968083875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.