ArticleRespiratory physiology & neurobiology2013
Respiratory modulation of lingual muscle activity across sleep-wake states in rats.
Article in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Increased tongue use enhances 5-HTRespiratory physiology & neurobiology · 2019Article
- Hypoglossal motoneurons are endogenously activated by serotonin during the active period of circadian cycle.Respiratory physiology & neurobiology · 2018Article
- Alterations of intrinsic tongue muscle properties with aging.Muscle & nerve · 2017Article
- Mechanisms of the deep, slow-wave, sleep-related increase of upper airway muscle tone in healthy humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Neural Control of the Upper Airway: Respiratory and State-Dependent Mechanisms.Comprehensive Physiology · 2016Review
- Brown Norway and Zucker Lean rats demonstrate circadian variation in ventilation and sleep apnea.Sleep · 2014Article
- Lingual muscle activity across sleep-wake States in rats with surgically altered upper airway.Frontiers in neurology · 2014Article
- Sleep and breathing. Foreword.Respiratory physiology & neurobiology · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In obstructive sleep apnea (OSA) patients, inspiratory activation (IA) of lingual muscles protects the upper airway from collapse. We aimed to determine when rats' lingual muscles exhibit IA. In 5 Sprague-Dawley and 3 Wistar rats, we monitored cortical EEG and lingual, diaphragmatic and nuchal electromyograms (EMGs), and identified segments of records when lingual EMG exhibited IA. Individual segments lasted 2.4-269 s (median: 14.5 s), most (89%) occurred during slow-wave sleep (SWS), and they collectively occupied 0.3-6.1% of the total recording time. IA usually started to increase with a delay after SWS onset and ended with an arousal, or declined prior to rapid eye movement sleep. IA of lingual EMG was not accompanied by increased diaphragmatic activity or respiratory rate changes, but occurred when cortical EEG power was particularly low in a low beta-1 frequency range (12.5-16.4 Hz). A deep SWS-related activation of upper airway muscles may be an endogenous phenomenon designed to protect the upper airway against collapse.
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