Evidence map›Paper›PMID 23732041›Full record

ArticleGenome biology2013

Deep C diving: mapping the low-abundance modifications of the DNA demethylation pathway.

John P Thomson, Jennifer M Hunter, Richard R Meehan

Abstract readComment
In one paragraph

Article in Genome biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Integrating DNA methylation dynamics into a framework for understanding epigenetic codes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014
    Review
  3. DNA demethylation pathways: recent insights.Genetics & epigenetics · 2013
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

John P Thomson
Jennifer M Hunter
Richard R Meehan

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council MC_PC_U127574433Medical Research Council MC_U127574433
6 · The paper itself

Abstract

Two new studies imply that the reprogramming of 5-methylcytosine via TET- and TDG-family enzymes is both widespread throughout the genome and functionally significant.

Indexed as

Epigenesis, GeneticGenetic TechniquesGenome-Wide Association Study5-MethylcytosineAnimalsCytosineEmbryonic Stem Cells5-MethylcytosineCytosine

Identifiers

PMID23732041
PMCPMC4054016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.