ArticleFoot (Edinburgh, Scotland)
Dual-energy X-ray absorptiometry of human metatarsals: precision, least significant change and association to ex vivo fracture force.
Article in Foot (Edinburgh, Scotland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Epidemiology of metatarsal fractures in Shropshire 2020-2023.Archives of osteoporosis · 2025Article
- Biomarkers of chronic kidney disease-mineral bone disorder (CKD-MBD) in the diabetic foot: A medical record review.Diabetes research and clinical practice · 2022Article
- Accelerated Cortical Osteolysis of Metatarsals in Charcot Neuroarthropathy: A Cross-Sectional Observational Study.JBMR plus · 2019Article
- Reliability of analysis of the bone mineral density of the second and fifth metatarsals using dual-energy x-ray absorptiometry (DXA).Journal of foot and ankle research · 2017Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFractures are common in foot bones, but clinicians lack adequate indices of bone strength.
objectivesWe used dual-energy X-ray absorptiometry (DXA) to measure bone mineral density (BMD) and content (BMC) of excised human metatarsals, determined intra- and inter-rater measurement precision, and assessed associations between BMD/BMC and ex vivo bone fracture strength.
methodsTwo raters each made two measurements of whole-bone and sub-regional BMD and BMC in both second and third metatarsals from 10 cadavers. Variance components analysis was used to assess variability attributable to repeat measurements, raters, sub-regions, bones, sides, and cadavers. Root-mean-square standard deviation (RMS-SD) and least-significant change (LSC) were used to assess rater precision and ultimate forces during 3-point bending were tested for correlations with BMD and BMC.
resultsVariation due to repeat measurements and rater was low (<1% combined) for BMD and BMC. RMS-SD for whole metatarsal BMD of both metatarsals ranged from 0.004 to 0.010 g/cm(2) and 0.062 to 0.086 g for BMC. Whole metatarsal and sub-region BMD and BMC were strongly correlated to ex vivo fracture force (r(2)=0.67-0.93).
conclusionsDXA measurements of BMD and BMC have high intra- and inter-rater precision and are strongly correlated to ex vivo bone strength.
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