ArticleDevelopmental psychology2014
Relating dopaminergic and cholinergic polymorphisms to spatial attention in infancy.
Article in Developmental psychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- A systematic review and meta-analysis of the relationship between genes and reflexive attention.Frontiers in neuroscience · 2025Pooled it
- Visual reflexive attention as a useful measure of development.Frontiers in psychology · 2023Review
- Assessing attention orienting in mice: a novel touchscreen adaptation of the Posner-style cueing task.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Rapid Infant Prefrontal Cortex Development and Sensitivity to Early Environmental Experience.Developmental review : DR · 2018Article
- Genetic associations with reflexive visual attention in infancy and childhood.Developmental science · 2017Article
- 5-HTTLPR polymorphism is linked to neural mechanisms of selective attention in preschoolers from lower socioeconomic status backgrounds.Developmental cognitive neuroscience · 2016Article
- MAOA Influences the Trajectory of Attentional Development.Frontiers in human neuroscience · 2016Article
- The molecular genetic architecture of attention deficit hyperactivity disorder.Molecular psychiatry · 2015Review
- Contributions of COMT Val¹⁵⁸ Met to cognitive stability and flexibility in infancy.Developmental science · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Early selective attention skills are a crucial building block for cognitive development, as attention orienting serves as a primary means by which infants interact with and learn from the environment. Although several studies have examined infants' attention orienting using the spatial cueing task, relatively few studies have examined neurodevelopmental factors associated with attention orienting during infancy. The present study examined the relationship between normative genetic polymorphisms affecting dopamine and acetylcholine signaling and attention orienting in 7-month-old infants during a spatial cueing task. We focused on 3 genes, including the CHRNA4 C¹⁵⁴⁵T SNP (rs10344946), DAT1 3'UTR VNTR, and COMT Val¹⁵⁸Met SNP (rs4680), as previous adult research has linked spatial attention skills to these polymorphisms. Behavioral measures included both facilitation of orienting at the cued location as well as inhibition of return (IOR), in which attention orienting is suppressed at the cued location. Results indicated that COMT Val carriers showed robust IOR relative to infants with the Met/Met genotype. However, COMT was unrelated to infants' facilitation responses, and there were no effects of CHRNA4 or DAT1 on either facilitation or IOR. Overall, this study suggests that variations in dopamine signaling, likely in prefrontal cortex, contribute to individual differences in orienting during early development.
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Registered trials
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