Evidence map›Paper›PMID 23731121›Full record

ArticleACS combinatorial science2013

Construction of a spirooxindole amide library through nitrile hydrozirconation-acylation-cyclization cascade.

Matthew G LaPorte, Sammi Tsegay, Ki Bum Hong, Chunliang Lu, Cheng Fang, Lirong Wang, Xiang-Qun Xie, Paul E Floreancig

Abstract read
In one paragraph

Article in ACS combinatorial science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew G LaPorteDepartment of Chemistry, Chemical Methodologies and Library Development, and ‡Department of Pharmaceutical Sciences, School of Pharmacy, Computational Chemical Genomics Screening Center, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
Sammi Tsegay
Ki Bum Hong
Chunliang Lu
Cheng Fang
Lirong Wang
Xiang-Qun Xie
Paul E Floreancig

Funding

University of Pittsburgh Center for Chemical DiversityP50GM067082 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WIPF, PETER · 2002 to 2012
$18.6M
Structure/Function of the CB2 Receptor Binding and G-protein Recognition PocketsR01DA025612 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIE, XIANG-QUN · 2010 to 2014
$1.7M
Screen and Design p18 Chemical Probes for Hematopoietic Stem Cell Self-RenewalR21HL109654 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIE, XIANG-QUN · 2011 to 2012
$413k
NHLBI NIH HHS R21 HL109654NHLBI NIH HHS R21HL109654NIDA NIH HHS R01 DA025612NIGMS NIH HHS P50 GM067082NIGMS NIH HHS P50GM067082
6 · The paper itself

Abstract

A library of spirooxindoles containing varied elements of structural and stereochemical diversity has been constructed via a three step, one pot nitrile hydrozirconation-acylation-cyclization reaction sequence from common acyclic indole intermediates. The resulting library was evaluated for novelty through comparison with MLSMR and Maybridge compound collections.

Indexed as

AcylationCombinatorial Chemistry TechniquesCyclizationIndolesNitrilesSpiro CompoundsZirconiumindoleIndolesNitrilesSpiro CompoundsZirconium

Identifiers

PMID23731121
PMCPMC3800499

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.