Evidence map›Paper›PMID 23731013›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2014

Evidence for shared genetic risk between ADHD symptoms and reduced mathematics ability: a twin study.

Corina U Greven, Yulia Kovas, Erik G Willcutt, Stephen A Petrill, Robert Plomin

Registry-linked trialAbstract readTwin Study
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02827188 (Cognitive Restructuring in ADHD), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02827188 nacompletednot on this mapstarted 2016, after this paper: background citation

Cognitive Restructuring in ADHD: Functional Training

TypeinterventionalSponsorThe Hospital for Sick ChildrenRan2016 to 2017Enrolled46ConditionsAttention-deficit Hyperactivity DisorderArmsMega Team-videogame
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Review
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  13. A Meta-Analytical Review of the Genetic and Environmental Correlations between Reading and Attention-Deficit Hyperactivity Disorder Symptoms and Reading and Math.Scientific studies of reading : the official journal of the Society for the Scientific Study of Reading · 2020
    Article
  14. Article
  15. Article
  16. Review
  17. Gene-Environment Interactions in ADHD: The Roles of SES and Chaos.Journal of abnormal child psychology · 2018
    Article
  18. Neuropsychology of Learning Disabilities: The Past and the Future.Journal of the International Neuropsychological Society : JINS · 2017
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Corina U GrevenRadboud University Medical Centre Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, The Netherlands; King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
Yulia Kovas
Erik G Willcutt
Stephen A Petrill
Robert Plomin

Funding

VALIDITY OF SUBTYPES OF ADHDP50HD027802 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI ERIK G WILLCUTT · 1990 to 2026
$44.9M
Genetics, School environments and cognitive developmentR01HD044454 · NICHD · KING'S COLLEGE LONDON · PI PLOMIN, ROBERT · 2005 to 2014
$3.4M
Etiology and Neuropsychology of Math, Reading, ADHD, and their CovariationR01HD068728 · NICHD · UNIVERSITY OF COLORADO · PI PETRILL, STEPHEN A., WILLCUTT, ERIK G · 2011 to 2015
$3.0M
Genetics of Mathematical Cognition and DisabilitiesR01HD059215 · NICHD · OHIO STATE UNIVERSITY · PI PETRILL, STEPHEN A. · 2009 to 2012
$2.4M
Neurobiological Underpinnings of Math and Reading Comorbidity: A Twin StudyR24HD075460 · NICHD · OHIO STATE UNIVERSITY · PI PETRILL, STEPHEN A. · 2012 to 2015
$2.4M
GENETICS OF GENERAL AND SPECIFIC MATH DISABILITIESR01HD046167 · NICHD · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI PETRILL, STEPHEN A · 2003 to 2005
$1.6M
Reading disability QTLs: pooled DNA on microarraysR01HD049861 · NICHD · KING'S COLLEGE LONDON · PI PLOMIN, ROBERT · 2006 to 2008
$794k
Medical Research Council G0500079Medical Research Council G0500079(73692)Medical Research Council G0901245Medical Research Council G19/2NICHD NIH HHS HD044454NICHD NIH HHS HD046167NICHD NIH HHS HD049861NICHD NIH HHS HD059215NICHD NIH HHS P50 HD027802NICHD NIH HHS R01 HD044454NICHD NIH HHS R01 HD046167NICHD NIH HHS R01 HD049861NICHD NIH HHS R01 HD059215NICHD NIH HHS R01 HD068728NICHD NIH HHS R24 HD075460NICHD NIH HHS R24HD075460
6 · The paper itself

Abstract

backgroundAttention-deficit/hyperactivity disorder (ADHD) symptoms and mathematics ability are associated, but little is known about the genetic and environmental influences underlying this association.

methodsData came from more than 6,000 twelve-year-old twin pairs from the UK population-representative Twins Early Development Study. Parents rated each twin's behaviour using a DSM-IV-based 18-item questionnaire of inattentive and hyperactive-impulsive ADHD symptoms. Mathematics tests based on the UK National Curriculum were completed by each twin. The twins also completed standardised tests of reading and general cognitive ability. Multivariate twin model fitting was applied.

resultsInattentive and hyperactive-impulsive ADHD symptoms were highly heritable (67% and 73% respectively). Mathematics ability was moderately heritable (46%). Mathematics ability and inattentiveness showed a significantly greater phenotypic correlation (r(p) = -.26) and genetic correlation (r(A) = -.41) than mathematics ability and hyperactivity-impulsivity (r(p) = -.18; r(A) = -.22). The genetic correlation between inattentiveness and mathematics ability was largely independent from hyperactivity-impulsivity, and was only partially accounted for by genetic influences related to reading and general cognitive ability.

conclusionsResults revealed the novel finding that mathematics ability shows significantly stronger phenotypic and genetic associations with inattentiveness than with hyperactivity-impulsivity. Genetic associations between inattentiveness and mathematics ability could only partially be accounted for by hyperactivity-impulsivity, reading and general cognitive ability. Results suggest that mathematics ability is associated with ADHD symptoms largely because it shares genetic risk factors with inattentiveness, and provide further evidence for considering inattentiveness and hyperactivity-impulsivity separately. DNA markers for ADHD symptoms (especially inattentiveness) may also be candidate risk factors for mathematics ability and vice versa.

Indexed as

MathematicsAttention Deficit Disorder with HyperactivityChildCognition DisordersComorbidityDiseases in TwinsEducational MeasurementFemaleHumansMaleMathematical ConceptsModels, PsychologicalProblem SolvingUnited KingdomADHDgeneral cognitive abilitygeneticsmathematicsreadingtwin study

Identifiers

PMID23731013
PMCPMC3865138

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.