ArticleInternational journal of circumpolar health2013
Dioxin-like compounds are not associated with bone strength measured by ultrasonography in Inuit women from Nunavik (Canada): results of a cross-sectional study.
Article in International journal of circumpolar health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Temporal trends of contaminants in Arctic human populations.Environmental science and pollution research international · 2018Review
- Overview of ongoing cohort and dietary studies in the Arctic.International journal of circumpolar health · 2016Article
- Health effects associated with measured levels of contaminants in the Arctic.International journal of circumpolar health · 2016Article
- Association between environmental contaminants and health outcomes in indigenous populations of the Circumpolar North.International journal of circumpolar health · 2014Review
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBone strength in Inuit people appears lower than that of non-Aboriginals. Inuit are exposed to persistent organic pollutants including dioxin-like compounds (DLCs) through their traditional diet that comprises predatory fish and marine mammal fat. Results from experimental and population studies suggest that some DLCs can alter bone metabolism and increase bone fragility.
objectiveThis cross-sectional descriptive study was conducted to examine the relationship between the stiffness index (SI) and plasma concentrations of total DLCs or specific dioxin-like polychlorinated biphenyls (DL-PCBs) in Inuit women of Nunavik (Northern Quebec, Canada).
methodsSI was determined by ultrasonography at the right calcaneus of 194 Inuit women aged 35-72 years who participated to Qanuippitaa? How Are We? Nunavik Inuit Health Survey in 2004. Plasma total DLC levels were quantified by measuring the aryl hydrocarbon receptor-mediated transcriptional activity elicited by plasma sample extracts in a cell-based reporter gene assay. Plasma concentrations of DL-PCBs nos. 105, 118, 156, 157, 167 and 189 were measured by gas chromatography-mass spectrometry. We used multiple linear regression analyses to investigate relations between total DLCs or specific DL-PCBs and SI, taking into consideration several potential confounders.
resultsNeither total plasma DLCs nor specific DL-PCBs were associated with SI after adjustment for several confounders and covariates.
conclusionOur results do not support a relation between exposure to DLCs and bone strength measured by ultrasonography in Inuit women of Nunavik.
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