ArticleAging and disease2013
Hippocampal oscillatory activity in Alzheimer's disease: toward the identification of early biomarkers?
Article in Aging and disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed.
- Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults.Neurobiology of aging · 2023Trial
- Protocol for semi-automatic quantitative bioimaging analysis of synapse loss.STAR protocols · 2026Article
- From brain waves to heartbeats: Exploring the combined role of electroencephalography and heart-rate variability in Alzheimer's disease diagnosis and management.Journal of Alzheimer's disease : JAD · 2026Review
- Alzheimer's genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses.Cell reports · 2025Article
- The gamma rhythm as a guardian of brain health.eLife · 2024Review
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- Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations.Aging and disease · 2024Review
- Modifying Alzheimer's disease pathophysiology with photobiomodulation: model, evidence, and future with EEG-guided intervention.Frontiers in neurology · 2024Review
- Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer's disease.Molecular psychiatry · 2023Review
- Compulsive-like Behaviors in Amyloid-β 1-42-Induced Alzheimer's Disease in Mice Are Associated With Hippocampo-cortical Neural Circuit Dysfunction.Biological psychiatry global open science · 2023Article
- Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults.medRxiv : the preprint server for health sciences · 2023Article
- Alterations of resting-state Gamma frequency characteristics in aging and Alzheimer's disease.Cognitive neurodynamics · 2023Article
- Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations.Acta neuropathologica communications · 2023Article
- Aberrant Dopamine System Function in the Ferrous Amyloid Buthionine (FAB) Rat Model of Alzheimer's Disease.International journal of molecular sciences · 2023Article
- Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer's disease neuropathologic change.Acta neuropathologica · 2023Article
- Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer's disease.Translational neurodegeneration · 2023Article
- Linking temporal coordination of hippocampal activity to memory function.Frontiers in cellular neuroscience · 2023Review
- Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease.Molecular neurodegeneration · 2022Review
- A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease.PLoS computational biology · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) develops for a yet unknown period of time and can progress undiagnosed for years before its first clinical manifestation consisting of characteristic cognitive impairments. Current AD treatments offer only a small symptomatic benefit, likely because AD is diagnosed when the pathology is already well advanced, whereas treatments may be most efficient in the early phases of pathology. An accurate, early marker of AD is therefore needed to help diagnose AD earlier. It is now well documented that AD patients and animal models of AD exhibit reorganization of hippocampal and cortical networks. This reorganization is initiated by an early imbalance between excitation and inhibition, leading to altered network activity. The mechanisms underlying these changes are unknown but recent evidence suggests that either soluble amyloid-beta (Aß) or fibrillar forms of Aß are central to various network alterations observed in AD. However, recent evidence also suggests that Aβ over-production in animal models is not systematically linked to network over-excitation. We hypothesize here that early changes in the excitation-inhibition balance within the hippocampus occurs much earlier than currently believed and initially produces only slight changes in overall hippocampal activity. In this review, we introduce the concept according to which the subtle changes in theta and gamma rhythms might occur during the very first stages of AD and thus could be used as a possible predictor for the disease.
Indexed as
Identifiers
23730529PMC3660123What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.