Evidence map›Paper›PMID 23730526›Full record

ArticleForum on immunopathological diseases and therapeutics2012

Nitric Oxide-Releasing Hybrid Drugs Target Cellular Processes Through S-Nitrosylation.

Khosrow Kashfi

Abstract read
In one paragraph

Article in Forum on immunopathological diseases and therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. S-Nitrosylation in Tumor Microenvironment.International journal of molecular sciences · 2021
    Review
  4. Review
  5. Article
  6. Review
  7. Nitrosothiol signaling and protein nitrosation in cell death.Nitric oxide : biology and chemistry · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Khosrow KashfiDepartment of Physiology, Pharmacology and Neuroscience, City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031; Tel.: (212) 650-6641; -7692.

Funding

Diazeniumdiolates as Broad-Spectrum Anticancer AgentsZIABC011188 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEEFER, LARRY K · 2009 to 2015
$5.2M
Intramural NIH HHS ZIA BC011188
6 · The paper itself

Abstract

Nitric oxide (NO)-releasing agents such as JS-K and NO-releasing hybrids such as NO- and NONO-nonsteroidal anti-inflammatory drugs are novel agents with great potential for controlling cancer. Although studied extensively, a key question pertaining to their molecular targets and mechanism of action remains unclear: the role of NO in the overall biological effect of these agents. It has been shown that NO can directly modify sulfhydryl residues of proteins through

Indexed as

caspase-3chemopreventioncolon cancerJS-KNF-κBnitric oxideNONO-NSAIDsNO-NSAIDsNSAIDsS-nitrosylationβ-catenin

Identifiers

PMID23730526
PMCPMC3666189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.