ArticleTherapeutic advances in endocrinology and metabolism2013
Improving major amputation rates in the multicomplex diabetic foot patient: focus on the severity of peripheral arterial disease.
Article in Therapeutic advances in endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Prognostic performance of bedside tests for predicting ulcer healing and wound healing after minor amputation in patients prone to medial arterial calcification: A systematic review.Vascular medicine (London, England) · 2025Pooled it
- Glycemic control and diabetic foot ulcer outcomes: A systematic review and meta-analysis of observational studies.Journal of diabetes and its complications · 2020Pooled it
- Cost-effectiveness of TLC-NOSF dressings versus neutral dressings for the treatment of diabetic foot ulcers in France.PloS one · 2021Trial
- Comorbid status in patients with osteomyelitis is associated with long-term incidence of extremity amputation.BMJ open diabetes research & care · 2023Observational
- Prognostic Value of Wagner Grade and Platelet Level in Diabetics with Infected Foot Ulcers After Antibiotic Therapy.Infection and drug resistance · 2023Article
- Development and use of the PodEssential and Paeds-PodEssential triage tools to define "essential" podiatry services. A Delphi survey, scoping review, and face validity testing study.Journal of foot and ankle research · 2022Article
- Psychometric evaluation of the Persian version of the diabetic foot self-care questionnaire in Iranian patients with diabetes.BMC endocrine disorders · 2021Article
- Silver Sulfadiazine Eradicates Antibiotic-TolerantJournal of clinical medicine · 2020Article
- Neutrophil Extracellular Traps Are Markers of Wound Healing Impairment in Patients with Diabetic Foot Ulcers Treated in a Multidisciplinary Setting.Advances in wound care · 2020Article
- Endovascular Devices and Revascularization Techniques for Limb-Threatening Ischemia in Individuals With Diabetes.Journal of diabetes science and technology · 2017Article
- Risk Factors for Foot Amputation in Patients Hospitalized for Diabetic Foot Infection.Journal of diabetes research · 2016Article
- Rates and predictors of readmission after minor lower extremity amputations.Journal of vascular surgery · 2015Article
- Article
- Role of comorbidities as limiting factors to the effect of hyperbaric oxygen in diabetic foot patients: a retrospective analysis.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2014Article
- Exenatide can inhibit calcification of human VSMCs through the NF-kappaB/RANKL signaling pathway.Cardiovascular diabetology · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePeripheral arterial disease (PAD), as well as diabetic neuropathy, is a risk factor for the development of diabetic foot ulcers. The aim of this study was to evaluate differences and predictors of outcome parameters in patients with diabetic foot by stratifying these subjects according to the severity of PAD. RESEARCH DESIGN AND
methodsIn a prospective study, patients with new diabetic foot ulcers have been treated and investigated by structured healthcare. Subjects were recruited between 1 January 2000 and 31 December 2007. All study participants underwent a 2-year follow-up observation period. The patients underwent a standardized examination and classification of their foot ulcers according to a modification of the University of Texas Wound Classification System. The severity of PAD was estimated by measurement of the ankle brachial index (ABI) and the continuous wave Doppler flow curve into undisturbed perfusion (0.9 < ABI < 1.3), compensated perfusion (0.5 < ABI < 0.9), decompensated perfusion (ABI < 0.5) and medial arterial calcification.
resultsA total of 678 patients with diabetic foot were consecutively included into the study (69% male, mean age 66.3 ± 11.0 years, mean diabetes duration 15.8 ± 10.2 years). Major amputations (above the ankle) were performed in 4.7% of the patients. 22.1% of these subjects had decompensated PAD. These subjects had delayed ulcer healing, higher risk for major amputation [odds ratio (OR) 7.7, 95% confidence interval (CI) 2.8-21.2, p < 0.001] and mortality (OR 4.9, 95 % CI 1.1-22.1, p < 0.05).
conclusionThis prospective study shows that the severity of PAD significantly influences the outcome of diabetic foot ulcers regarding to wound healing, major amputation and mortality.
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