ArticleInterventional neurology2013
Fractional Flow in Cerebrovascular Disorders.
Article in Interventional neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Non-Invasive functional assessment of severity in cerebral arterial stenosis using cerebral flow fraction: A hemodynamic study.Medical & biological engineering & computing · 2026Article
- A systematic evaluation of the impact of contralateral stenosis on ipsilateral internal carotid artery hemodynamics using computational fluid dynamics.Quantitative imaging in medicine and surgery · 2025Article
- Integrating hemodynamic analysis with traditional imaging in intracranial atherosclerotic stenosis: current status and future perspectives.Frontiers in neurology · 2025Review
- Angiography‑based quantitative flow ratio for functional assessment of intracranial atherosclerotic disease.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
- Differential sensitivities to blood pressure variations in internal carotid and intracranial arteries: a numerical approach to stroke prediction.Scientific reports · 2023Article
- A magnetic resonance imaging-based computational analysis of cerebral hemodynamics in patients with carotid artery stenosis.Quantitative imaging in medicine and surgery · 2023Article
- Can intracranial time-of-flight-MR angiography predict extracranial carotid artery stenosis?Journal of neurology · 2022Article
- Hemodynamic and Geometric Risk Factors for In-Stent Restenosis in Patients with Intracranial Atherosclerotic Stenosis.Oxidative medicine and cellular longevity · 2022Article
- Functional Assessment of Cerebral Artery Stenosis by Angiography-Based Quantitative Flow Ratio: A Pilot Study.Frontiers in aging neuroscience · 2022Article
- Noninvasive quantification of cerebrovascular pressure changes using 4D Flow MRI.Magnetic resonance in medicine · 2021Article
- Cerebral venous steal equation for intracranial segmental perfusion pressure predicts and quantifies reversible intracranial to extracranial flow diversion.Scientific reports · 2021Article
- Prevalence, prognosis, and treatment of atherosclerotic intracranial stenosis in Caucasians.International journal of stroke : official journal of the International Stroke Society · 2021Article
- A Combined Computational Fluid Dynamics and Arterial Spin Labeling MRI Modeling Strategy to Quantify Patient-Specific Cerebral Hemodynamics in Cerebrovascular Occlusive Disease.Frontiers in bioengineering and biotechnology · 2021Article
- Comparison of Newtonian and Non-newtonian Fluid Models in Blood Flow Simulation in Patients With Intracranial Arterial Stenosis.Frontiers in physiology · 2021Article
- Sustaining cerebral perfusion in intracranial atherosclerotic stenosis: The roles of antegrade residual flow and leptomeningeal collateral flow.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Semi-automated analysis of 4D flow MRI to assess the hemodynamic impact of intracranial atherosclerotic disease.Magnetic resonance in medicine · 2019Article
- Association of Fractional Flow on 3D-TOF-MRA with Cerebral Perfusion in Patients with MCA Stenosis.AJNR. American journal of neuroradiology · 2019Article
- Functional assessment of cerebral artery stenosis: A pilot study based on computational fluid dynamics.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Physiome approach for the analysis of vascular flow reserve in the heart and brain.Pflugers Archiv : European journal of physiology · 2017Review
- Advanced Imaging of Intracranial Atherosclerosis: Lessons from Interventional Cardiology.Frontiers in neurology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
There is an urgent need for stroke experts to advance the care of their patients, yet current approaches are outmoded and have not been successful. The traditional emphasis on anatomical identification of disease, using percent luminal stenosis, results in suboptimal identification of lesions likely to produce recurrent ischemia and, consequently, results in poor patient selection and hampers the development of new aggressive treatments. The traditional emphasis on time since symptom onset and alleged need to achieve complete revascularization in patients with acute ischemic stroke ignores the very nature and degree of the underlying culprit lesion and hampers our understanding of the relationships between the patient's original ischemic state, revascularization, reperfusion, reperfusion injury and hemorrhagic transformation. The trajectory for the study and care of cerebrovascular patients needs to adapt, as it has in cardiology, employing hemodynamics and pathophysiology as the new guideposts for advancement. We introduce fractional flow as one hemodynamic parameter to be utilized to set a course on this new path for the care of stroke patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.